Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer’s disease

Abstract The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 synapses by acute Aβ application in adult neurons from rodents, young amyloid precurs...

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Bibliographic Details
Main Authors: Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry, Mariana Vargas-Caballero
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Online Access:http://link.springer.com/article/10.1186/s40478-019-0670-1

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http://link.springer.com/article/10.1186/s40478-019-0670-1

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