ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.

Homologous recombination (HR) is required for the restart of collapsed DNA replication forks and error-free repair of DNA double-strand breaks (DSB). However, unscheduled or hyperactive HR may lead to genomic instability and promote cancer development. The cellular factors that restrict HR processes...

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Bibliographic Details
Main Authors: Bianca M Sirbu, Sarah J Lachmayer, Verena Wülfing, Lara M Marten, Katie E Clarkson, Linda W Lee, Liliana Gheorghiu, Lee Zou, Simon N Powell, Jochen Dahm-Daphi, Henning Willers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3155521?pdf=render

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http://europepmc.org/articles/PMC3155521?pdf=render

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