MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, s...

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Bibliographic Details
Main Authors: C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25325-9