AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression

Abstract Background Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson’s disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the late-onset PD. Advanced glycation en...

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Bibliographic Details
Main Authors: Hyun Jin Cho, Chengsong Xie, Huaibin Cai
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
LRRK2
G2019S
AGE
RAGE
Neuronal death
Online Access:http://link.springer.com/article/10.1186/s40035-018-0106-z

Internet

http://link.springer.com/article/10.1186/s40035-018-0106-z

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