Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Disease

Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Disease

Cerebral β-amyloidosis, an accumulation in the patient’s brain of aggregated amyloid-β (Aβ) peptides abnormally saturated by divalent biometal ions, is one of the hallmarks of Alzheimer’s disease (AD). Earlier, we found that exogenously administrated synthetic Aβ with isomerized Asp7 (isoD7-Aβ) indu...

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Bibliographic Details
Main Authors: Sergey A. Kozin, Evgeny P. Barykin, Georgy B. Telegin, Alexander S. Chernov, Alexei A. Adzhubei, Sergey P. Radko, Vladimir A. Mitkevich, Alexander A. Makarov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
amyloid-β peptide
zinc
isoaspartate
serine phosphorylation
transgenic mice
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00518/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00518/full

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