The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats

The Interplay of Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress in Cardiovascular Fibrosis in Obese Rats

We have evaluated the role of mitochondrial oxidative stress and its association with endoplasmic reticulum (ER) stress activation in the progression of obesity-related cardiovascular fibrosis. MitoQ (200 µM) was orally administered for 7 weeks to male Wistar rats that were fed a high-fat diet (HFD,...

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Bibliographic Details
Main Authors: Francisco V. Souza-Neto, Sara Jiménez-González, Beatriz Delgado-Valero, Raquel Jurado-López, Marie Genty, Ana Romero-Miranda, Cristina Rodríguez, María Luisa Nieto, Ernesto Martínez-Martínez, Victoria Cachofeiro
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
cardiovascular fibrosis
endoplasmic reticulum stress
mitochondrial oxidative stress
obesity
Online Access:https://www.mdpi.com/2076-3921/10/8/1274

Internet

https://www.mdpi.com/2076-3921/10/8/1274

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