Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

Abstract Huntington’s disease (HD) is a late onset, inherited neurodegenerative disorder for which early pathogenic events remain poorly understood. Here we show that mutant exon 1 HTT proteins are recruited to a subset of cytoplasmic aggregates in the cell bodies of neurons in brain sections from p...

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Bibliographic Details
Main Authors: Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Subjects:
Huntington’s disease
Correlative light and electron microscopy
Electron tomography
Huntingtin aggregation
Polyglutamine
Endolysosomal system
Online Access:https://doi.org/10.1186/s40478-021-01172-z

Internet

https://doi.org/10.1186/s40478-021-01172-z

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