Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

by Pinaki Misra, Ravindra Kodali, Saketh Chemuru, Karunakar Kar, Ronald Wetzel
Published 2016-08-01

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease

by Kenneth W. Drombosky, Sascha Rode, Ravi Kodali, Tija C. Jacob, Michael J. Palladino, Ronald Wetzel
Published 2018-12-01

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.

by Bankanidhi Sahoo, Irene Arduini, Kenneth W Drombosky, Ravindra Kodali, Laurie H Sanders, J Timothy Greenamyre, Ronald Wetzel
Published 2016-01-01

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

by Hsiang-Kai Lin, Jennifer C. Boatz, Inge E. Krabbendam, Ravindra Kodali, Zhipeng Hou, Ronald Wetzel, Amalia M. Dolga, Michelle A. Poirier, Patrick C. A. van der Wel
Published 2017-05-01

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease

by Ya Zhou, Thomas R. Peskett, Christian Landles, John B. Warner, Kirupa Sathasivam, Edward J. Smith, Shu Chen, Ronald Wetzel, Hilal A. Lashuel, Gillian P. Bates, Helen R. Saibil
Published 2021-04-01