Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and in-vitro generation of cell therapy products. In particular, iPSC-derived NK cells gained interest in adoptive anti-...

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Bibliographic Details
Main Authors: Johanna Euchner, Jasmin Sprissler, Toni Cathomen, Daniel Fürst, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Kerstin Felgentreff
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
induced pluripotent stem cells (iPSC)
natural killer (NK) cells
hematopoietic progenitor cells (HPC)
NK cell differentiation
OP9-DL1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640672/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.640672/full

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