Chimerization Enables Gene Synthesis and Lentiviral Delivery of Customizable TALE-Based Effectors

by Yongxing Fang, Wladislaw Stroukov, Toni Cathomen, Claudio Mussolino
Published 2020-01-01

Traceless Targeting and Isolation of Gene-Edited Immortalized Keratinocytes from Epidermolysis Bullosa Simplex Patients

by Magomet Aushev, Ulrich Koller, Claudio Mussolino, Toni Cathomen, Julia Reichelt
Published 2017-09-01

Generation of a gene-corrected isogenic control iPSC line from cystic fibrosis patient-specific iPSCs homozygous for p.Phe508del mutation mediated by TALENs and ssODN

by Sylvia Merkert, Christien Bednarski, Gudrun Göhring, Toni Cathomen, Ulrich Martin
Published 2017-08-01

Inhibition of replication of hepatitis B virus using transcriptional repressors that target the viral DNA

by Kristie Bloom, Haajira Kaldine, Toni Cathomen, Claudio Mussolino, Abdullah Ely, Patrick Arbuthnot
Published 2019-09-01

Genome Editing of the <i>SNAI1</i> Gene in Rhabdomyosarcoma: A Novel Model for Studies of Its Role

by Aleksandra Ulman, Klaudia Skrzypek, Paweł Konieczny, Claudio Mussolino, Toni Cathomen, Marcin Majka
Published 2020-04-01

Targeted Integration of a Super-Exon into the CFTR Locus Leads to Functional Correction of a Cystic Fibrosis Cell Line Model.

by Christien Bednarski, Katja Tomczak, Beate Vom Hövel, Wolf-Michael Weber, Toni Cathomen
Published 2016-01-01

TALE-PvuII fusion proteins--novel tools for gene targeting.

by Mert Yanik, Jamal Alzubi, Thomas Lahaye, Toni Cathomen, Alfred Pingoud, Wolfgang Wende
Published 2013-01-01

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

by Johanna Euchner, Johanna Euchner, Jasmin Sprissler, Jasmin Sprissler, Toni Cathomen, Toni Cathomen, Daniel Fürst, Daniel Fürst, Hubert Schrezenmeier, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Klaus Schwarz, Kerstin Felgentreff
Published 2021-05-01

Improved Specificity and Safety of Anti-Hepatitis B Virus TALENs Using Obligate Heterodimeric <i>Fok</i>I Nuclease Domains

by Tiffany Smith, Prashika Singh, Kay Ole Chmielewski, Kristie Bloom, Toni Cathomen, Patrick Arbuthnot, Abdullah Ely
Published 2021-07-01

Assessing the differential impact of chronic CMV and treated HIV infection on CD8+ T-cell differentiation in a matched cohort study: is CMV the key?

by Matthias C. Mueller, Winfried V. Kern, Susanne Usadel, Marie-Christin Pauly, Toni Cathomen, Ulrich Salzer
Published 2021-06-01

Impaired axonal transport in motor neurons correlates with clinical prion disease.

by Vladimir Ermolayev, Toni Cathomen, Julia Merk, Mike Friedrich, Wolfgang Härtig, Gregory S Harms, Michael A Klein, Eckhard Flechsig
Published 2009-08-01

An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

by Anie P. Masilamani, Viviane Dettmer-Monaco, Gianni Monaco, Toni Cathomen, Irina Kuckuck, Susanne Schultze-Seemann, Nathalie Huber, Philipp Wolf
Published 2020-06-01

Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome.

by Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn
Published 2010-01-01

PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model

by Jamal Alzubi, Viviane Dettmer-Monaco, Johannes Kuehle, Niko Thorausch, Maximilian Seidl, Sanaz Taromi, Wolfgang Schamel, Robert Zeiser, Hinrich Abken, Toni Cathomen, Philipp Wolf
Published 2020-09-01

Efficient Designer Nuclease-Based Homologous Recombination Enables Direct PCR Screening for Footprintless Targeted Human Pluripotent Stem Cells

by Sylvia Merkert, Stephanie Wunderlich, Christien Bednarski, Jennifer Beier, Alexandra Haase, Anne-Kathrin Dreyer, Kristin Schwanke, Johann Meyer, Gudrun Göhring, Toni Cathomen, Ulrich Martin
Published 2014-01-01

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient <i>in vitro</i> Clearance of iPSCs and iPSC-Macrophages

by Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Published 2020-04-01

Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases.

by Anna Osiak, Frank Radecke, Eva Guhl, Sarah Radecke, Nadine Dannemann, Fabienne Lütge, Silke Glage, Cornelia Rudolph, Tobias Cantz, Klaus Schwarz, Regine Heilbronn, Toni Cathomen
Published 2011-01-01

Modeling MyD88 Deficiency In Vitro Provides New Insights in Its Function

by Nils Craig-Mueller, Nils Craig-Mueller, Nils Craig-Mueller, Ruba Hammad, Ruba Hammad, Ruba Hammad, Roland Elling, Roland Elling, Roland Elling, Jamal Alzubi, Jamal Alzubi, Barbara Timm, Barbara Timm, Julia Kolter, Julia Kolter, Nele Knelangen, Nele Knelangen, Christien Bednarski, Christien Bednarski, Birgitta Gläser, Sandra Ammann, Sandra Ammann, Zoltán Ivics, Judith Fischer, Judith Fischer, Carsten Speckmann, Carsten Speckmann, Carsten Speckmann, Klaus Schwarz, Nico Lachmann, Nico Lachmann, Stephan Ehl, Stephan Ehl, Stephan Ehl, Thomas Moritz, Thomas Moritz, Philipp Henneke, Philipp Henneke, Philipp Henneke, Philipp Henneke, Toni Cathomen, Toni Cathomen, Toni Cathomen
Published 2020-12-01

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

by Shamim H Rahman, Johannes Kuehle, Christian Reimann, Tafadzwa Mlambo, Jamal Alzubi, Morgan L Maeder, Heimo Riedel, Paul Fisch, Tobias Cantz, Cornelia Rudolph, Claudio Mussolino, J Keith Joung, Axel Schambach, Toni Cathomen
Published 2015-05-01

Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells

by Nicole Cordes, Carolin Kolbe, Dominik Lock, Tatjana Holzer, Deborah Althoff, Daniel Schäfer, Franziska Blaeschke, Bettina Kotter, Sandra Karitzky, Claudia Rossig, Toni Cathomen, Tobias Feuchtinger, Iris Bürger, Mario Assenmacher, Thomas Schaser, Andrew D. Kaiser
Published 2021-06-01