Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer’s disease therapy

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer’s disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC50 = 11....

Full description

Bibliographic Details
Main Authors: Irene Pachón-Angona, Bernard Refouvelet, Rudolf Andrýs, Helène Martin, Vincent Luzet, Isabel Iriepa, Ignacio Moraleda, Daniel Diez-Iriepa, María-Jesús Oset-Gasque, José Marco-Contelles, Kamil Musilek, Lhassane Ismaili
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
antioxidant
cholinesterases
donepezil
mao-a
mao-b
orac
ugi-4mcr
Online Access:http://dx.doi.org/10.1080/14756366.2018.1545766

Internet

http://dx.doi.org/10.1080/14756366.2018.1545766

Similar Items