Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension

Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension

Pulmonary arterial hypertension (PAH) is a rare but fatal disease characterized by persistent elevated blood pressure in the pulmonary circulation, due to increased resistance to blood flow, through the lungs. Advances in the understanding of the pathobiology of PAH clarify the role of leukotrienes...

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Bibliographic Details
Main Authors: Angela Liparulo, Renata Esposito, Debora Santonocito, Alejandra Muñoz-Ramírez, Giuseppe Spaziano, Ferdinando Bruno, Jianbo Xiao, Carmelo Puglia, Rosanna Filosa, Liberato Berrino, Bruno D'Agostino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary arterial hypertension
solid lipid nanoparticles
5-lipoxygenase
inflammation
monocrotaline
RF-22c
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00083/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00083/full

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