Single cell derived mRNA signals across human kidney tumors
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23949-5 |
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doaj-07a679f9a06e4d84ac2da9b571bfc2a42021-06-27T11:13:06ZengNature Publishing GroupNature Communications2041-17232021-06-0112111910.1038/s41467-021-23949-5Single cell derived mRNA signals across human kidney tumorsMatthew D. Young0Thomas J. Mitchell1Lars Custers2Thanasis Margaritis3Francisco Morales-Rodriguez4Kwasi Kwakwa5Eleonora Khabirova6Gerda Kildisiute7Thomas R. W. Oliver8Ronald R. de Krijger9Marry M. van den Heuvel-Eibrink10Federico Comitani11Alice Piapi12Eva Bugallo-Blanco13Christine Thevanesan14Christina Burke15Elena Prigmore16Kirsty Ambridge17Kenny Roberts18Felipe A. Vieira Braga19Tim H. H. Coorens20Ignacio Del Valle21Anna Wilbrey-Clark22Lira Mamanova23Grant D. Stewart24Vincent J. Gnanapragasam25Dyanne Rampling26Neil Sebire27Nicholas Coleman28Liz Hook29Anne Warren30Muzlifah Haniffa31Marcel Kool32Stefan M. Pfister33John C. Achermann34Xiaoling He35Roger A. Barker36Adam Shlien37Omer A. Bayraktar38Sarah A. Teichmann39Frank C. Holstege40Kerstin B. Meyer41Jarno Drost42Karin Straathof43Sam Behjati44Wellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonPrincess Máxima Center for Pediatric OncologyPrincess Máxima Center for Pediatric OncologyPrincess Máxima Center for Pediatric OncologyWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonPrincess Máxima Center for Pediatric OncologyPrincess Máxima Center for Pediatric OncologyProgram in Genetics and Genome Biology, The Hospital for Sick ChildrenUCL Great Ormond Street Hospital Institute of Child HealthUCL Great Ormond Street Hospital Institute of Child HealthUCL Great Ormond Street Hospital Institute of Child HealthUCL Great Ormond Street Hospital Institute of Child HealthWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonAmsterdam UMC, University of AmsterdamWellcome Sanger Institute, Wellcome Genome Campus, HinxtonUCL Great Ormond Street Hospital Institute of Child HealthWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonCambridge University Hospitals NHS Foundation TrustCambridge University Hospitals NHS Foundation TrustGreat Ormond Street Hospital for Children NHS Foundation TrustNIHR Great Ormond Street Hospital BRC and Institute of Child HealthCambridge University Hospitals NHS Foundation TrustCambridge University Hospitals NHS Foundation TrustCambridge University Hospitals NHS Foundation TrustWellcome Sanger Institute, Wellcome Genome Campus, HinxtonPrincess Máxima Center for Pediatric OncologyHopp Children´s Cancer Center Heidelberg (KiTZ)UCL Great Ormond Street Hospital Institute of Child HealthMRC-WT Cambridge Stem Cell Institute, University of CambridgeMRC-WT Cambridge Stem Cell Institute, University of CambridgeProgram in Genetics and Genome Biology, The Hospital for Sick ChildrenWellcome Sanger Institute, Wellcome Genome Campus, HinxtonWellcome Sanger Institute, Wellcome Genome Campus, HinxtonPrincess Máxima Center for Pediatric OncologyWellcome Sanger Institute, Wellcome Genome Campus, HinxtonPrincess Máxima Center for Pediatric OncologyUCL Great Ormond Street Hospital Institute of Child HealthWellcome Sanger Institute, Wellcome Genome Campus, HinxtonTranscriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.https://doi.org/10.1038/s41467-021-23949-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati |
| spellingShingle |
Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati Single cell derived mRNA signals across human kidney tumors Nature Communications |
| author_facet |
Matthew D. Young Thomas J. Mitchell Lars Custers Thanasis Margaritis Francisco Morales-Rodriguez Kwasi Kwakwa Eleonora Khabirova Gerda Kildisiute Thomas R. W. Oliver Ronald R. de Krijger Marry M. van den Heuvel-Eibrink Federico Comitani Alice Piapi Eva Bugallo-Blanco Christine Thevanesan Christina Burke Elena Prigmore Kirsty Ambridge Kenny Roberts Felipe A. Vieira Braga Tim H. H. Coorens Ignacio Del Valle Anna Wilbrey-Clark Lira Mamanova Grant D. Stewart Vincent J. Gnanapragasam Dyanne Rampling Neil Sebire Nicholas Coleman Liz Hook Anne Warren Muzlifah Haniffa Marcel Kool Stefan M. Pfister John C. Achermann Xiaoling He Roger A. Barker Adam Shlien Omer A. Bayraktar Sarah A. Teichmann Frank C. Holstege Kerstin B. Meyer Jarno Drost Karin Straathof Sam Behjati |
| author_sort |
Matthew D. Young |
| title |
Single cell derived mRNA signals across human kidney tumors |
| title_short |
Single cell derived mRNA signals across human kidney tumors |
| title_full |
Single cell derived mRNA signals across human kidney tumors |
| title_fullStr |
Single cell derived mRNA signals across human kidney tumors |
| title_full_unstemmed |
Single cell derived mRNA signals across human kidney tumors |
| title_sort |
single cell derived mrna signals across human kidney tumors |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-06-01 |
| description |
Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors. |
| url |
https://doi.org/10.1038/s41467-021-23949-5 |
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