A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

A Drosophila model of dominant inclusion body myopathy type 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects

Individuals with inclusion body myopathy type 3 (IBM3) display congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood. The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa. We have prev...

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Bibliographic Details
Main Authors: Jennifer A. Suggs, Girish C. Melkani, Bernadette M. Glasheen, Mia M. Detor, Anju Melkani, Nathan P. Marsan, Douglas M. Swank, Sanford I. Bernstein
Format: Article
Language:English
Published: The Company of Biologists 2017-06-01
Series:Disease Models & Mechanisms
Subjects:
Inclusion body myopathy type 3
Myosin heavy chain
Drosophila melanogaster
Myofibril
Muscle mechanics
Online Access:http://dmm.biologists.org/content/10/6/761

Internet

http://dmm.biologists.org/content/10/6/761

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