Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats.

Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in Sprague-Dawley rats.

Gene expression profiling is a tool to gain mechanistic understanding of adverse effects in response to compound exposure. However, little is known about how the common handling procedures of experimental animals during a preclinical study alter baseline gene expression. We report gene expression ch...

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Bibliographic Details
Main Authors: Yudong D He, Christine M Karbowski, Jon Werner, Nancy Everds, Chris Di Palma, Yuan Chen, Marnie Higgins-Garn, Sandra Tran, Cynthia A Afshari, Hisham K Hamadeh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3925150?pdf=render

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http://europepmc.org/articles/PMC3925150?pdf=render

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