The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

Medium-chain fatty acids (MCFAs) have been associated with anti-steatotic effects in hepatocytes. Expression of the MCFA receptor GPR84 (G protein-coupled receptor 84) is induced in immune cells under inflammatory conditions and can promote fibrogenesis. We aimed at deciphering the role of GPR84 in...

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Bibliographic Details
Main Authors: Tobias Puengel, Steve De Vos, Jana Hundertmark, Marlene Kohlhepp, Nurdan Guldiken, Philippe Pujuguet, Marielle Auberval, Florence Marsais, Kenji F. Shoji, Laurent Saniere, Christian Trautwein, Tom Luedde, Pavel Strnad, Reginald Brys, Philippe Clément-Lacroix, Frank Tacke
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Journal of Clinical Medicine
Subjects:
monocytes
macrophages
neutrophils
fatty acid
medium-chain fatty acid
G protein-coupled receptor 84 (GPR84)
Online Access:https://www.mdpi.com/2077-0383/9/4/1140

Internet

https://www.mdpi.com/2077-0383/9/4/1140

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