The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis

by Tobias Puengel, Steve De Vos, Jana Hundertmark, Marlene Kohlhepp, Nurdan Guldiken, Philippe Pujuguet, Marielle Auberval, Florence Marsais, Kenji F. Shoji, Laurent Saniere, Christian Trautwein, Tom Luedde, Pavel Strnad, Reginald Brys, Philippe Clément-Lacroix, Frank Tacke
Published 2020-04-01

Targeting of αv-Integrins in Stem/Progenitor Cells and Supportive Microenvironment Impairs Bone Metastasis in Human Prostate Cancer

by Geertje van der Horst, Christel van den Hoogen, Jeroen T. Buijs, Henry Cheung, Henny Bloys, Rob C.M. Pelger, Giocondo Lorenzon, Bertrand Heckmann, Jean Feyen, Philippe Pujuguet, Roland Blanque, Philippe Clément-Lacroix, Gabri van der Pluijm
Published 2011-06-01

The Small Molecule Ephrin Receptor Inhibitor, GLPG1790, Reduces Renewal Capabilities of Cancer Stem Cells, Showing Anti-Tumour Efficacy on Preclinical Glioblastoma Models

by Giovanni Luca Gravina, Andrea Mancini, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Loredana Cristiano, Stefano Martellucci, Francesco Marampon, Vincenzo Mattei, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Giocondo Lorenzon, Ellen van der Aar, Claudio Festuccia
Published 2019-03-01

Antitumorigenic Effects of Inhibiting Ephrin Receptor Kinase Signaling by GLPG1790 against Colorectal Cancer Cell Lines In Vitro and In Vivo

by Alessandro Colapietro, Giovanni Luca Gravina, Francesco Petragnano, Irene Fasciani, Bianca Maria Scicchitano, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Daniela Musio, Francesca De Felice, Vincenzo Mattei, Stefano Martellucci, Roberto Maggio, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
Published 2020-01-01

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embr...

by Francesca Megiorni, Giovanni Luca Gravina, Simona Camero, Simona Ceccarelli, Andrea Del Fattore, Vincenzo Desiderio, Federica Papaccio, Heather P. McDowell, Rajeev Shukla, Antonio Pizzuti, Filip Beirinckx, Philippe Pujuguet, Laurent Saniere, Ellen Van der Aar, Roberto Maggio, Francesca De Felice, Cinzia Marchese, Carlo Dominici, Vincenzo Tombolini, Claudio Festuccia, Francesco Marampon
Published 2017-10-01