Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs

Quantitation of a Novel Engineered Anti-infective Host Defense Peptide, ARV-1502: Pharmacokinetic Study of Different Doses in Rats and Dogs

The designer proline-rich antimicrobial peptide (PrAMP) Chex1-Arg20 amide (ARV-1502) is active against Gram-negative and Gram-positive pathogens in different murine infection models when administered parenterally and possesses a wide therapeutic index. Here we studied the pharmacokinetics of ARV-150...

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Bibliographic Details
Main Authors: Alexandra Brakel, Daniela Volke, Carl N. Kraus, Laszlo Otvos, Ralf Hoffmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Chemistry
Subjects:
antimicrobial peptide (AMP)
Beagle dogs
Chex1-Arg20 amide
parallel reaction monitoring (PRM)
pharmacokinetics
proline-rich AMP
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00753/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00753/full

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