PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates

Summary: Most triacylglycerol-lowering fibrates have been developed in the 1960s–1980s before their molecular target, peroxisome proliferator-activated receptor alpha (PPARα), was identified. Twenty-one ligand-bound PPARα structures have been deposited in the Protein Data Bank since 2001; however, b...

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Bibliographic Details
Main Authors: Shotaro Kamata, Takuji Oyama, Kenta Saito, Akihiro Honda, Yume Yamamoto, Keisuke Suda, Ryo Ishikawa, Toshimasa Itoh, Yasuo Watanabe, Takahiro Shibata, Koji Uchida, Makoto Suematsu, Isao Ishii
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:iScience
Subjects:
Biochemistry
Molecular Physiology
Structural Biology
Protein Structure Aspects
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030924X

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http://www.sciencedirect.com/science/article/pii/S258900422030924X

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