TGF-β induced senescence is a novel therapeutic target for treating osteoporosis in Gerodermia Osteodysplastica

by Wing Lee Chan, Jonathan Goldes, Magdalena Steiner, Alvin C. Ma, Stefan Mundlos, Uwe Kornak
Published 2020-10-01

The effect of a deteriorated architecture of the lacunocanalicular network on the organization and mineralization of the extracellular matrix

by Andreas Roschger, Alexander F. van Tol, Michael Thelen, Anne Seliger, Haisheng Yang, Wing Lee Chan, Tobias Thiele, Paul Roschger, Georg N. Duda, Paul Zaslansky, Uwe Kornak, Bettina M. Willie, Richard Weinkamer
Published 2020-10-01

Deletions, Inversions, Duplications: Engineering of Structural Variants using CRISPR/Cas in Mice

by Katerina Kraft, Sinje Geuer, Anja J. Will, Wing Lee Chan, Christina Paliou, Marina Borschiwer, Izabela Harabula, Lars Wittler, Martin Franke, Daniel M. Ibrahim, Bjørt K. Kragesteen, Malte Spielmann, Stefan Mundlos, Darío G. Lupiáñez, Guillaume Andrey
Published 2015-02-01

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

by Tomasz M. Witkos, Wing Lee Chan, Merja Joensuu, Manuel Rhiel, Ed Pallister, Jane Thomas-Oates, A. Paul Mould, Alex A. Mironov, Christophe Biot, Yann Guerardel, Willy Morelle, Daniel Ungar, Felix T. Wieland, Eija Jokitalo, May Tassabehji, Uwe Kornak, Martin Lowe
Published 2019-01-01

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplast...

by Wing Lee Chan, Magdalena Steiner, Tomasz Witkos, Johannes Egerer, Björn Busse, Shuji Mizumoto, Jan M Pestka, Haikuo Zhang, Ingrid Hausser, Layal Abo Khayal, Claus-Eric Ott, Mateusz Kolanczyk, Bettina Willie, Thorsten Schinke, Chiara Paganini, Antonio Rossi, Kazuyuki Sugahara, Michael Amling, Petra Knaus, Danny Chan, Martin Lowe, Stefan Mundlos, Uwe Kornak
Published 2018-03-01