DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer

by Marie Stiborová, Volker M. Arlt, Heinz H. Schmeiser
Published 2017-10-01

Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches

by Marie Stiborová, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Published 2014-06-01

The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductas...

by Marie Stiborová, Věra Černá, Michaela Moserová, Iveta Mrízová, Volker M. Arlt, Eva Frei
Published 2014-12-01

C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.

by Bedoor Qabazard, Samanza Ahmed, Ling Li, Volker M Arlt, Philip K Moore, Stephen R Stürzenbaum
Published 2013-01-01

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells

by Tereza Cerna, Jan Hrabeta, Tomas Eckschlager, Eva Frei, Heinz H. Schmeiser, Volker M. Arlt, Marie Stiborová
Published 2018-01-01

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1

by Jan Milichovký, František Bárta, Heinz H. Schmeiser, Volker M. Arlt, Eva Frei, Marie Stiborová, Václav Martínek
Published 2016-02-01

A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches

by Marie Stiborová, František Bárta, Kateřina Levová, Petr Hodek, Heinz H. Schmeiser, Volker M. Arlt, Václav Martínek
Published 2015-11-01

Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C₆₀) in Toxicological Response of Marine Mussels

by Audrey Barranger, Laura M. Langan, Vikram Sharma, Graham A. Rance, Yann Aminot, Nicola J. Weston, Farida Akcha, Michael N. Moore, Volker M. Arlt, Andrei N. Khlobystov, James W. Readman, Awadhesh N. Jha
Published 2019-07-01

Assessing the impact of Benzo[a]pyrene on Marine Mussels: Application of a novel targeted low density microarray complementing classical biomarker responses.

by Mohamed Banni, Susanna Sforzini, Volker M Arlt, Audrey Barranger, Lorna J Dallas, Caterina Oliveri, Yann Aminot, Beniamina Pacchioni, Caterina Millino, Gerolamo Lanfranchi, James W Readman, Michael N Moore, Aldo Viarengo, Awadhesh N Jha
Published 2017-01-01

Blocking TGF-β Signaling Pathway Preserves Mitochondrial Proteostasis and Reduces Early Activation of PDGFRβ+ Pericytes in Aristolochic Acid Induced Acute Kidney Injury in Wistar M...

by Agnieszka A Pozdzik, Laetitia Giordano, Gang Li, Marie-Hélène Antoine, Nathalie Quellard, Julie Godet, Eric De Prez, Cécile Husson, Anne-Emilie Declèves, Volker M Arlt, Jean-Michel Goujon, Isabelle Brochériou-Spelle, Steven R Ledbetter, Nathalie Caron, Joëlle L Nortier
Published 2016-01-01