The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes

by Robert C. Sharp, Matthew E. Brown, Melanie R. Shapiro, Amanda L. Posgai, Todd M. Brusko, Todd M. Brusko
Published 2021-09-01

Isogenic Cellular Systems Model the Impact of Genetic Risk Variants in the Pathogenesis of Type 1 Diabetes

by Mark A. Wallet, Katherine E. Santostefano, Naohiro Terada, Todd M. Brusko
Published 2017-10-01

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive...

by Maigan A. Brusko, Maigan A. Brusko, Joshua M. Stewart, Amanda L. Posgai, Clive H. Wasserfall, Mark A. Atkinson, Mark A. Atkinson, Todd M. Brusko, Todd M. Brusko, Benjamin G. Keselowsky
Published 2020-10-01

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension

by Andrew J. Bryant, Borna Mehrad, Todd M. Brusko, James D. West, Lyle L. Moldawer
Published 2018-08-01

Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

by Todd M Brusko, Clive H Wasserfall, Maigan A Hulme, Roniel Cabrera, Desmond Schatz, Mark A Atkinson
Published 2009-11-01

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.

by Tatiana N Golovina, Tatiana Mikheeva, Todd M Brusko, Bruce R Blazar, Jeffrey A Bluestone, James L Riley
Published 2011-01-01

Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability Relative to Adult Peripheral Blood

by Keshav Motwani, Leeana D. Peters, Willem H. Vliegen, Ahmed Gomaa El-sayed, Howard R. Seay, M. Cecilia Lopez, Henry V. Baker, Amanda L. Posgai, Maigan A. Brusko, Daniel J. Perry, Rhonda Bacher, Joseph Larkin, Michael J. Haller, Todd M. Brusko, Todd M. Brusko
Published 2020-04-01

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

by Melanie R. Shapiro, Wen-I Yeh, Joshua R. Longfield, John Gallagher, Caridad M. Infante, Sarah Wellford, Amanda L. Posgai, Mark A. Atkinson, Mark A. Atkinson, Martha Campbell-Thompson, Scott M. Lieberman, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Todd M. Brusko, Todd M. Brusko
Published 2020-09-01

Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells

by Seung-Chul Choi, Anton A. Titov, Georges Abboud, Howard R. Seay, Todd M. Brusko, Derry C. Roopenian, Shahram Salek-Ardakani, Laurence Morel
Published 2018-10-01

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

by Wen-I Yeh, Howard R. Seay, Brittney Newby, Amanda L. Posgai, Filipa Botelho Moniz, Aaron Michels, Clayton E. Mathews, Jeffrey A. Bluestone, Todd M. Brusko
Published 2017-10-01

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

by Debalina Sarkar, Moanaro Biswas, Gongxian Liao, Howard R Seay, George Q Perrin, David M Markusic, Brad E Hoffman, Todd M Brusko, Cox Terhorst, Roland W Herzog
Published 2014-01-01

A checkpoint on innate myeloid cells in pulmonary arterial hypertension

by Andrew J. Bryant, Chunhua Fu, Yuanquing Lu, Mark L. Brantly, Borna Mehrad, Lyle L. Moldawer, Todd M. Brusko, Evan L. Brittain, James D. West, Eric D. Austin, Rizwan Hamid
Published 2019-01-01

Regulatory T-cells from pancreatic lymphnodes of patients with type-1 diabetes express increased levels of microRNA miR-125a-5p that limits CCR2 expression

by Guido Sebastiani, Giuliana Ventriglia, Angela Stabilini, Carlo Socci, Cristina Morsiani, Andrea Laurenzi, Laura Nigi, Caterina Formichi, Bechara Mfarrej, Alessandra Petrelli, Georgia Fousteri, Todd M. Brusko, Francesco Dotta, Manuela Battaglia
Published 2017-07-01

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.

by Todd M Brusko, Richard C Koya, Shirley Zhu, Michael R Lee, Amy L Putnam, Stephanie A McClymont, Michael I Nishimura, Shuhong Han, Lung-Ji Chang, Mark A Atkinson, Antoni Ribas, Jeffrey A Bluestone
Published 2010-07-01

Lactobacillus johnsonii N6.2 Modulates the Host Immune Responses: A Double-Blind, Randomized Trial in Healthy Adults

by Guillermo E. Marcial, Amanda L. Ford, Michael J. Haller, Salvador A. Gezan, Natalie A. Harrison, Dan Cai, Julie L. Meyer, Daniel J. Perry, Mark A. Atkinson, Clive H. Wasserfall, Timothy Garrett, Claudio F. Gonzalez, Todd M. Brusko, Wendy J. Dahl, Graciela L. Lorca
Published 2017-06-01

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes

by Faheem W. Guirgis, Lauren Page Black, Morgan Henson, Guillaume Labilloy, Carmen Smotherman, Charlotte Hopson, Ian Tfirn, Elizabeth L. DeVos, Christiaan Leeuwenburgh, Lyle Moldawer, Susmita Datta, Todd M. Brusko, Alexis Hester, Andrew Bertrand, Victor Grijalva, Alexander Arango-Esterhay, Frederick A. Moore, Srinivasa T. Reddy
Published 2021-09-01

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis

by Dijoia B. Darden, Xiaoru Dong, Maigan A. Brusko, Lauren Kelly, Brittany Fenner, Jaimar C. Rincon, Marvin L. Dirain, Ricardo Ungaro, Dina C. Nacionales, Marie Gauthier, Michael Kladde, Todd M. Brusko, Azra Bihorac, Frederick A. Moore, Tyler Loftus, Rhonda Bacher, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Published 2021-08-01

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy

by Howard R. Seay, Amy L. Putnam, Judit Cserny, Amanda L. Posgai, Emma H. Rosenau, John R. Wingard, Kate F. Girard, Morey Kraus, Angela P. Lares, Heather L. Brown, Katherine S. Brown, Kristi T. Balavage, Leeana D. Peters, Ashley N. Bushdorf, Mark A. Atkinson, Jeffrey A. Bluestone, Michael J. Haller, Todd M. Brusko
Published 2017-03-01

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

by Anke Fuchs, Mateusz Gliwiński, Nathali Grageda, Rachel Spiering, Abul K. Abbas, Silke Appel, Rosa Bacchetta, Manuela Battaglia, David Berglund, Bruce Blazar, Jeffrey A. Bluestone, Martin Bornhäuser, Anja ten Brinke, Todd M. Brusko, Nathalie Cools, Maria Cristina Cuturi, Edward Geissler, Nick Giannoukakis, Karolina Gołab, David A. Hafler, S. Marieke van Ham, Joanna Hester, Keli Hippen, Mauro Di Ianni, Natasa Ilic, John Isaacs, John Isaacs, Fadi Issa, Dorota Iwaszkiewicz-Grześ, Elmar Jaeckel, Irma Joosten, David Klatzmann, Hans Koenen, Cees van Kooten, Olle Korsgren, Olle Korsgren, Karsten Kretschmer, Karsten Kretschmer, Megan Levings, Natalia Maria Marek-Trzonkowska, Marc Martinez-Llordella, Djordje Miljkovic, Kingston H.G. Mills, Joana P. Miranda, Ciriaco A. Piccirillo, Amy L. Putnam, Thomas Ritter, Maria Grazia Roncarolo, Shimon Sakaguchi, Silvia Sánchez-Ramón, Birgit Sawitzki, Ljiljana Sofronic-Milosavljevic, Megan Sykes, Qizhi Tang, Marta Vives-Pi, Herman Waldmann, Piotr Witkowski, Kathryn J. Wood, Silvia Gregori, Catharien M. U. Hilkens, Giovanna Lombardi, Phillip Lord, Eva M. Martinez-Caceres, Piotr Trzonkowski
Published 2018-01-01