Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.

by Sarah R Leist, Kara L Jensen, Ralph S Baric, Timothy P Sheahan
Published 2019-01-01

A mechanism‐based pharmacokinetic model of remdesivir leveraging interspecies scaling to simulate COVID‐19 treatment in humans

by Patrick O. Hanafin, Brian Jermain, Anthony J. Hickey, Alexander V. Kabanov, Angela DM. Kashuba, Timothy P. Sheahan, Gauri G. Rao
Published 2021-02-01

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

by Lisa E. Gralinski, Timothy P. Sheahan, Thomas E. Morrison, Vineet D. Menachery, Kara Jensen, Sarah R. Leist, Alan Whitmore, Mark T. Heise, Ralph S. Baric
Published 2018-10-01

Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses

by Vy Tran, Daniel S. Poole, Justin J. Jeffery, Timothy P. Sheahan, Donald Creech, Aleksey Yevtodiyenko, Andrew J. Peat, Kevin P. Francis, Shihyun You, Andrew Mehle
Published 2015-10-01

Virus–Host Interactions Between Nonsecretors and Human NorovirusSummary

by Lisa C. Lindesmith, Paul D. Brewer-Jensen, Michael L. Mallory, Kara Jensen, Boyd L. Yount, Veronica Costantini, Matthew H. Collins, Caitlin E. Edwards, Timothy P. Sheahan, Jan Vinjé, Ralph S. Baric
Published 2020-01-01

Conformational Occlusion of Blockade Antibody Epitopes, a Novel Mechanism of GII.4 Human Norovirus Immune Evasion

by Lisa C. Lindesmith, Michael L. Mallory, Kari Debbink, Eric F. Donaldson, Paul D. Brewer-Jensen, Excel W. Swann, Timothy P. Sheahan, Rachel L. Graham, Martina Beltramello, Davide Corti, Antonio Lanzavecchia, Ralph S. Baric, Ana Fernandez-Sesma
Published 2018-02-01

Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice

by David R. Martinez, Alexandra Schäfer, Sarah R. Leist, Dapeng Li, Kendra Gully, Boyd Yount, Joy Y. Feng, Elaine Bunyan, Danielle P. Porter, Tomas Cihlar, Stephanie A. Montgomery, Barton F. Haynes, Ralph S. Baric, Michel C. Nussenzweig, Timothy P. Sheahan
Published 2021-07-01

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

by Maria L. Agostini, Erica L. Andres, Amy C. Sims, Rachel L. Graham, Timothy P. Sheahan, Xiaotao Lu, Everett Clinton Smith, James Brett Case, Joy Y. Feng, Robert Jordan, Adrian S. Ray, Tomas Cihlar, Dustin Siegel, Richard L. Mackman, Michael O. Clarke, Ralph S. Baric, Mark R. Denison, Kanta Subbarao
Published 2018-03-01

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

by Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schäfer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
Published 2020-01-01

Hypergraph models of biological networks to identify genes critical to pathogenic viral response

by Song Feng, Emily Heath, Brett Jefferson, Cliff Joslyn, Henry Kvinge, Hugh D. Mitchell, Brenda Praggastis, Amie J. Eisfeld, Amy C. Sims, Larissa B. Thackray, Shufang Fan, Kevin B. Walters, Peter J. Halfmann, Danielle Westhoff-Smith, Qing Tan, Vineet D. Menachery, Timothy P. Sheahan, Adam S. Cockrell, Jacob F. Kocher, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bramer, Michael S. Diamond, Ralph S. Baric, Katrina M. Waters, Yoshihiro Kawaoka, Jason E. McDermott, Emilie Purvine
Published 2021-05-01