Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases

by Diana F. Lázaro, Arianna Bellucci, Patrik Brundin, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro
Published 2020-01-01

Protein phosphorylation in neurodegeneration: friend or foe?

by Sandra eTenreiro, Katrin eEckermann, Tiago F Outeiro, Tiago F Outeiro
Published 2014-05-01

Zebrafish as an Animal Model for Drug Discovery in Parkinson’s Disease and Other Movement Disorders: A Systematic Review

by Rita L. Vaz, Rita L. Vaz, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Joaquim J. Ferreira, Joaquim J. Ferreira, Joaquim J. Ferreira
Published 2018-06-01

SIRT2 as a therapeutic target for age-related disorders

by RIta eMachado de Oliveira, Jana eSarkander, Aleksey G. Kazantsev, Aleksey G. Kazantsev, Tiago F Outeiro, Tiago F Outeiro, Tiago F Outeiro
Published 2012-05-01

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

by Inês C. Brás, Tiago F. Outeiro
Published 2021-02-01

Editorial on Special Topic: Sirtuins in Metabolism, Aging and Disease

by Aleksey G. Kazantsev, Tiago F. Outeiro
Published 2012-04-01

Identification of Two Novel Peptides That Inhibit α-Synuclein Toxicity and Aggregation

by Blagovesta Popova, Dan Wang, Abirami Rajavel, Karthikeyan Dhamotharan, Diana F. Lázaro, Jennifer Gerke, Joachim F. Uhrig, Michael Hoppert, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Gerhard H. Braus
Published 2021-04-01

Editorial: Molecular Chaperones and Neurodegeneration

by Cintia Roodveldt, Tiago F. Outeiro, Janice E. A. Braun
Published 2017-10-01

MPV17 Mutations Are Associated With a Quiescent Energetic Metabolic Profile

by Sandra Jacinto, Sandra Jacinto, Patrícia Guerreiro, Patrícia Guerreiro, Patrícia Guerreiro, Rita Machado de Oliveira, Teresa Cunha-Oliveira, Maria João Santos, Maria João Santos, Maria João Santos, Manuela Grazina, Manuela Grazina, Manuela Grazina, Ana Cristina Rego, Ana Cristina Rego, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro
Published 2021-03-01

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.

by Ellen Gerhardt, Simone Gräber, Eva M Szego, Nicoleta Moisoi, L Miguel Martins, Tiago F Outeiro, Pawel Kermer
Published 2011-01-01

C-Terminal Tyrosine Residue Modifications Modulate the Protective Phosphorylation of Serine 129 of α-Synuclein in a Yeast Model of Parkinson's Disease.

by Alexandra Kleinknecht, Blagovesta Popova, Diana F Lázaro, Raquel Pinho, Oliver Valerius, Tiago F Outeiro, Gerhard H Braus
Published 2016-06-01

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology

by Rita F. Belo, Rita F. Belo, Margarida L. F. Martins, Margarida L. F. Martins, Liana Shvachiy, Tiago Costa-Coelho, Tiago Costa-Coelho, Carolina de Almeida-Borlido, Carolina de Almeida-Borlido, João Fonseca-Gomes, João Fonseca-Gomes, Vera Neves, Vera Neves, Hugo Vicente Miranda, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Tiago F. Outeiro, Joana E. Coelho, Sara Xapelli, Sara Xapelli, Cláudia A. Valente, Cláudia A. Valente, Montserrat Heras, Eduard Bardaji, Miguel A. R. B. Castanho, Miguel A. R. B. Castanho, Maria José Diógenes, Maria José Diógenes, Ana M. Sebastião, Ana M. Sebastião
Published 2020-07-01

Antibodies against alpha-synuclein reduce oligomerization in living cells.

by Thomas Näsström, Susana Gonçalves, Charlotte Sahlin, Eva Nordström, Valentina Screpanti Sundquist, Lars Lannfelt, Joakim Bergström, Tiago F Outeiro, Martin Ingelsson
Published 2011-01-01

The influence of dopamine-beta-hydroxylase and catechol O-methyltransferase gene polymorphism on the efficacy of insulin detemir therapy in patients with type 2 diabetes mellitus

by Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F. Outeiro, Nela Pivac, Fran Borovecki
Published 2017-12-01

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity

by Anita Carija, Francisca Pinheiro, Jordi Pujols, Inês C. Brás, Diana Fernandes Lázaro, Carlo Santambrogio, Rita Grandori, Tiago F. Outeiro, Susanna Navarro, Salvador Ventura
Published 2019-04-01

Dopamine-induced conformational changes in alpha-synuclein.

by Tiago F Outeiro, Jochen Klucken, Kathryn Bercury, Julie Tetzlaff, Preeti Putcha, Luis M A Oliveira, Alexandre Quintas, Pamela J McLean, Bradley T Hyman
Published 2009-09-01

Membrane binding, internalization, and sorting of alpha-synuclein in the cell

by Caterina Masaracchia, Marilena Hnida, Ellen Gerhardt, Tomás Lopes da Fonseca, Anna Villar-Pique, Tiago Branco, Markus A. Stahlberg, Camin Dean, Claudio O. Fernández, Ira Milosevic, Tiago F. Outeiro
Published 2018-08-01

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.

by Blagovesta Popova, Dan Wang, Christina Pätz, Dagmar Akkermann, Diana F Lázaro, Dajana Galka, Miriam Kolog Gulko, Markus T Bohnsack, Wiebke Möbius, Katherine E Bohnsack, Tiago F Outeiro, Gerhard H Braus
Published 2021-03-01

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

by Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf, Jia-Yi Li
Published 2019-06-01

(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis

by Diana Macedo, Carolina Jardim, Inês Figueira, A. Filipa Almeida, Gordon J. McDougall, Derek Stewart, Jose E. Yuste, Francisco A. Tomás-Barberán, Sandra Tenreiro, Tiago F. Outeiro, Cláudia N. Santos
Published 2018-05-01