Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications

by Anoop Mistry, Thomas Scambler, David Parry, Mark Wood, Gabriela Barcenas-Morales, Clive Carter, Rainer Doffinger, Sinisa Savic, Sinisa Savic
Published 2017-11-01

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

by Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Published 2019-09-01

Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness...

by Stephanie R. Harrison, Thomas Scambler, Lylia Oubussad, Chi Wong, Miriam Wittmann, Miriam Wittmann, Miriam Wittmann, Michael F. McDermott, Sinisa Savic, Sinisa Savic, Sinisa Savic
Published 2018-02-01

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

by Samuel Lara-Reyna, Samuel Lara-Reyna, Samuel Lara-Reyna, Thomas Scambler, Thomas Scambler, Jonathan Holbrook, Jonathan Holbrook, Jonathan Holbrook, Chi Wong, Chi Wong, Chi Wong, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Fabio Martinon, Fabio Martinon, Sinisa Savic, Sinisa Savic, Sinisa Savic, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott
Published 2019-08-01

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

by Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Published 2020-03-01