Neurodegenerative Disease and the NLRP3 Inflammasome

by Jonathan A. Holbrook, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Emily Caseley, Emily Caseley, Samuel Lara-Reyna, James A. Poulter, James A. Poulter, Caroline H. Williams-Gray, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott
Published 2021-03-01

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

by Samuel Lara-Reyna, Samuel Lara-Reyna, Samuel Lara-Reyna, Thomas Scambler, Thomas Scambler, Jonathan Holbrook, Jonathan Holbrook, Jonathan Holbrook, Chi Wong, Chi Wong, Chi Wong, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Heledd H. Jarosz-Griffiths, Fabio Martinon, Fabio Martinon, Sinisa Savic, Sinisa Savic, Sinisa Savic, Daniel Peckham, Daniel Peckham, Daniel Peckham, Michael F. McDermott, Michael F. McDermott
Published 2019-08-01

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

by Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Published 2019-09-01

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1

by Mark L. Dallas, Moza M. Al-Owais, Nishani T. Hettiarachchi, Matthew Scott Vandiver, Heledd H. Jarosz-Griffiths, Jason L. Scragg, John P. Boyle, Derek Steele, Chris Peers
Published 2021-04-01

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

by Heledd H Jarosz-Griffiths, Thomas Scambler, Chi H Wong, Samuel Lara-Reyna, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Paul Whitaker, Christine Etherington, Giulia Spoletini, Ian Clifton, Anil Mehta, Michael F McDermott, Daniel Peckham
Published 2020-03-01