The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities

by Hyeyoun Chang, Zhenying Cai, Thomas M. Roberts
Published 2019-11-01

Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

by Onur Cizmecioglu, Jing Ni, Shaozhen Xie, Jean J Zhao, Thomas M Roberts
Published 2016-10-01

A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells

by Yubao Wang, Ben B. Li, Jing Li, Thomas M. Roberts, Jean J. Zhao
Published 2018-11-01

The role of the PIK3CA gene in the development and aging of the brain

by Shaozhen Xie, Jing Ni, Hanbing Guo, Victor Luu, Yanzhi Wang, Jean J. Zhao, Thomas M. Roberts
Published 2021-01-01

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells

by Jing Zhang, Xueliang Gao, Fabienne Schmit, Guillaume Adelmant, Michael J. Eck, Jarrod A. Marto, Jean J. Zhao, Thomas M. Roberts
Published 2017-07-01

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.

by Shuji Kishi, Peter E Bayliss, Junzo Uchiyama, Eriko Koshimizu, Jie Qi, Purushothama Nanjappa, Shintaro Imamura, Asiful Islam, Donna Neuberg, Adam Amsterdam, Thomas M Roberts
Published 2008-08-01

PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer

by Jennifer M. Spangle, Koen M. Dreijerink, Anna C. Groner, Hailing Cheng, Carolynn E. Ohlson, Jaime Reyes, Charles Y. Lin, James Bradner, Jean J. Zhao, Thomas M. Roberts, Myles Brown
Published 2016-06-01

K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.

by Irmgard Hofmann, Andreas Weiss, Gaelle Elain, Maria Schwaederle, Dario Sterker, Vincent Romanet, Tobias Schmelzle, Albert Lai, Saskia M Brachmann, Mohamed Bentires-Alj, Thomas M Roberts, William R Sellers, Francesco Hofmann, Sauveur-Michel Maira
Published 2012-01-01

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.

by Shintaro Imamura, Junzo Uchiyama, Eriko Koshimizu, Jun-Ichi Hanai, Christina Raftopoulou, Ryan D Murphey, Peter E Bayliss, Yoichi Imai, Caroline Erter Burns, Kenkichi Masutomi, Sarantis Gagos, Leonard I Zon, Thomas M Roberts, Shuji Kishi
Published 2008-01-01

Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer

by Su Jeong Song, Seohyun Kim, Seong A Kim, Gi-Hoon Nam, Gi Beom Kim, Yoonjeong Choi, Minsu Kwon, Cherlhyun Jeong, Hanul Jung, Eunbyeol Ko, Yeji Lee, Jihoon Han, Jiwan Woo, Yakdol Cho, Seung-Yoon Park, Thomas M. Roberts, Yong Beom Cho
Published 2021-07-01

PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

by Liya Ding, Hye-Jung Kim, Qiwei Wang, Michael Kearns, Tao Jiang, Carolynn E. Ohlson, Ben B. Li, Shaozhen Xie, Joyce F. Liu, Elizabeth H. Stover, Brooke E. Howitt, Roderick T. Bronson, Suzan Lazo, Thomas M. Roberts, Gordon J. Freeman, Panagiotis A. Konstantinopoulos, Ursula A. Matulonis, Jean J. Zhao
Published 2018-12-01