Characterizing biomarker features of cognitively normal individuals with ventriculomegaly

by Xiaofeng Li, Maowen Ba, Kok Pin Ng, Sulantha Mathotaarachchi, Tharick A. Pascoal, Pedro Rosa‐Neto, Serge Gauthier, Alzheimer's Disease Neuroimaging Initiative
Published 2018-01-01

Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease

by Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A. Pascoal, Pedro Rosa-Neto, Serge Gauthier, the Alzheimer’s Disease Neuroimaging Initiative
Published 2018-08-01

Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease

by Hua Zhang, Kok Pin Ng, Joseph Therriault, Min Su Kang, Tharick A. Pascoal, Pedro Rosa-Neto, Serge Gauthier, the Alzheimer’s Disease Neuroimaging Initiative
Published 2018-09-01

Imaging Alzheimer's disease pathophysiology with PET

by Lucas Porcello Schilling, Eduardo R. Zimmer, Monica Shin, Antoine Leuzy, Tharick A. Pascoal, Andréa L. Benedet, Wyllians Vendramini Borelli, André Palmini, Serge Gauthier, Pedro Rosa-Neto

Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [18F]THK5351 uptake in progressive supranuclear palsy

by Kok Pin Ng, Joseph Therriault, Min Su Kang, Hanne Struyfs, Tharick A Pascoal, Sulantha Mathotaarachchi, Monica Shin, Andrea L Benedet, Gassan Massarweh, Jean-Paul Soucy, Pedro Rosa-Neto, Serge Gauthier
Published 2019-01-01

Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer’s disease

by Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Yiong Huak Chan, Lai Jiang, Joseph Therriault, Andrea L. Benedet, Monica Shin, Nagaendran Kandiah, Celia M. T. Greenwood, Pedro Rosa-Neto, Serge Gauthier, Dominantly Inherited Alzheimer Network
Published 2021-01-01

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

by Kok Pin Ng, Tharick A. Pascoal, Sulantha Mathotaarachchi, Joseph Therriault, Min Su Kang, Monica Shin, Marie-Christine Guiot, Qi Guo, Ryuichi Harada, Robert A. Comley, Gassan Massarweh, Jean-Paul Soucy, Nobuyuki Okamura, Serge Gauthier, Pedro Rosa-Neto
Published 2017-03-01

Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment

by Tharick A. Pascoal, Joseph Therriault, Sulantha Mathotaarachchi, Min Su Kang, Monica Shin, Andrea L. Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Sara Mohaddes, Jean‐Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa‐Neto, for the Alzheimer's Disease Neuroimaging Initiative
Published 2020-01-01

Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid‐positive individuals

by Andréa L. Benedet, Nicholas J. Ashton, Tharick A. Pascoal, Antoine Leuzy, Sulantha Mathotaarachchi, Min S. Kang, Joseph Therriault, Melissa Savard, Mira Chamoun, Michael Schöll, Eduardo R. Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Kaj Blennow, Pedro R. Neto, Alzheimer's Disease Neuroimaging Initiative
Published 2019-12-01

In vivo quantification of neurofibrillary tangles with [18F]MK-6240

by Tharick A. Pascoal, Monica Shin, Min Su Kang, Mira Chamoun, Daniel Chartrand, Sulantha Mathotaarachchi, Idriss Bennacef, Joseph Therriault, Kok Pin Ng, Robert Hopewell, Reda Bouhachi, Hung-Hsin Hsiao, Andrea L. Benedet, Jean-Paul Soucy, Gassan Massarweh, Serge Gauthier, Pedro Rosa-Neto
Published 2018-07-01

Aβ-induced vulnerability propagates via the brain’s default mode network

by Tharick A. Pascoal, Sulantha Mathotaarachchi, Min Su Kang, Sara Mohaddes, Monica Shin, Ah Yeon Park, Maxime J. Parent, Andrea L. Benedet, Mira Chamoun, Joseph Therriault, Heungsun Hwang, A. Claudio Cuello, Bratislav Misic, Jean-Paul Soucy, John A. D. Aston, Serge Gauthier, Pedro Rosa-Neto
Published 2019-06-01

Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease

by Cécile Tissot, Andréa L. Benedet, Joseph Therriault, Tharick A. Pascoal, Firoza Z. Lussier, Paramita Saha-Chaudhuri, Mira Chamoun, Melissa Savard, Sulantha S. Mathotaarachchi, Gleb Bezgin, Yi-Ting Wang, Jaime Fernandez Arias, Juan Lantero Rodriguez, Anniina Snellman, Nicholas J. Ashton, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Etienne De Villers-Sidani, Philippe Huot, Serge Gauthier, Pedro Rosa-Neto, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2021-03-01

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

by Natalia M. Lyra e Silva, Rafaella A. Gonçalves, Tharick A. Pascoal, Ricardo A. S. Lima-Filho, Elisa de Paula França Resende, Erica L. M. Vieira, Antonio L. Teixeira, Leonardo C. de Souza, Julyanna A. Peny, Juliana T. S. Fortuna, Isadora C. Furigo, Debora Hashiguchi, Vivian S. Miya-Coreixas, Julia R. Clarke, Jose F. Abisambra, Beatriz M. Longo, Jose Donato, Paul E. Fraser, Pedro Rosa-Neto, Paulo Caramelli, Sergio T. Ferreira, Fernanda G. De Felice
Published 2021-04-01

A multicentre validation study of the diagnostic value of plasma neurofilament light

by Nicholas J. Ashton, Shorena Janelidze, Ahmad Al Khleifat, Antoine Leuzy, Emma L. van der Ende, Thomas K. Karikari, Andrea L. Benedet, Tharick A. Pascoal, Alberto Lleó, Lucilla Parnetti, Daniela Galimberti, Laura Bonanni, Andrea Pilotto, Alessandro Padovani, Jan Lycke, Lenka Novakova, Markus Axelsson, Latha Velayudhan, Gil D. Rabinovici, Bruce Miller, Carmine Pariante, Naghmeh Nikkheslat, Susan M. Resnick, Madhav Thambisetty, Michael Schöll, Gorka Fernández-Eulate, Francisco J. Gil-Bea, Adolfo López de Munain, Ammar Al-Chalabi, Pedro Rosa-Neto, Andre Strydom, Per Svenningsson, Erik Stomrud, Alexander Santillo, Dag Aarsland, John C. van Swieten, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Abdul Hye, Oskar Hansson
Published 2021-06-01