Integration of Immunome With Disease-Gene Network Reveals Common Cellular Mechanisms Between IMIDs and Drug Repurposing Strategies

by Abhinandan Devaprasad, Abhinandan Devaprasad, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Aridaman Pandit, Aridaman Pandit
Published 2021-05-01

A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis

by T. W. van Hal, L. van Bon, T. R. D. J. Radstake
Published 2011-01-01

Fc gamma receptor IIb on GM-CSF macrophages controls immune complex mediated inhibition of inflammatory signals.

by Kim C M Santegoets, Mark H Wenink, Wim B van den Berg, Timothy R D J Radstake
Published 2014-01-01

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

by Tiago Carvalheiro, Tiago Carvalheiro, Samuel Garcia, Samuel Garcia, Samuel Garcia, Samuel Garcia, M. Inês Pascoal Ramos, M. Inês Pascoal Ramos, Barbara Giovannone, Barbara Giovannone, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Wioleta Marut, Wioleta Marut, Linde Meyaard, Linde Meyaard
Published 2020-08-01

The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis

by Barbara Mariotti, Nila Hendrika Servaas, Nila Hendrika Servaas, Marzia Rossato, Marzia Rossato, Marzia Rossato, Nicola Tamassia, Marco A. Cassatella, Marta Cossu, Marta Cossu, Lorenzo Beretta, Maarten van der Kroef, Maarten van der Kroef, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Flavia Bazzoni
Published 2019-01-01

Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner

by Tiago Carvalheiro, Carlos Rafael-Vidal, Beatriz Malvar-Fernandez, Ana P. Lopes, Jose M. Pego-Reigosa, Timothy R. D. J. Radstake, Samuel Garcia
Published 2020-09-01

High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis

by Fleurieke H. Verhagen, Fleurieke H. Verhagen, Fleurieke H. Verhagen, Sanne Hiddingh, Sanne Hiddingh, Rianne Rijken, Aridaman Pandit, Aridaman Pandit, Emmerik Leijten, Emmerik Leijten, Michel Olde Nordkamp, Ninette H. ten Dam-van Loon, Stefan Nierkens, Saskia M. Imhof, Joke H. de Boer, Joke H. de Boer, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Jonas J. W. Kuiper, Jonas J. W. Kuiper, Jonas J. W. Kuiper
Published 2018-10-01

Characterization of Long Non-Coding RNAs in Systemic Sclerosis Monocytes: A Potential Role for PSMB8-AS1 in Altered Cytokine Secretion

by Nila H. Servaas, Barbara Mariotti, Maarten van der Kroef, Catharina G. K. Wichers, Aridaman Pandit, Flavia Bazzoni, Timothy R. D. J. Radstake, Marzia Rossato
Published 2021-04-01

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

by Roos A. W. Wennink, Roos A. W. Wennink, Aridaman Pandit, Anne-Mieke J. W. Haasnoot, Anne-Mieke J. W. Haasnoot, Sanne Hiddingh, Viera Kalinina Ayuso, Nico M. Wulffraat, Bas J. Vastert, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joke H. de Boer, Jonas J. W. Kuiper, Jonas J. W. Kuiper
Published 2020-09-01

Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.

by Carmen A Ambarus, Kim C M Santegoets, Lenny van Bon, Mark H Wenink, Paul P Tak, Timothy R D J Radstake, Dominique L P Baeten
Published 2012-01-01

The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Anila Hussiani, Roger Hesselstrand, Dirk M Wuttge, Yanhui Deng, Robbert Simms, Erik Lubberts, Robert Lafyatis
Published 2009-06-01

Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Mark Wenink, Kim Santegoets, Yanhui Deng, Anila Hussaini, Robert Simms, William W Cruikshank, Robert Lafyatis
Published 2009-06-01

Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren’s Syndrome Patients Identifies CCL5 as a Novel Effector Molecule

by Anneline C. Hinrichs, Anneline C. Hinrichs, Sofie L. M. Blokland, Sofie L. M. Blokland, Ana P. Lopes, Ana P. Lopes, Catharina G. K. Wichers, Catharina G. K. Wichers, Aike A. Kruize, Aridaman Pandit, Aridaman Pandit, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon
Published 2021-07-01

The Additive Inflammatory In Vivo and In Vitro Effects of IL-7 and TSLP in Arthritis Underscore the Therapeutic Rationale for Dual Blockade.

by Maarten R Hillen, Sarita A Y Hartgring, Cynthia R Willis, Timothy R D J Radstake, Cornelis E Hack, Floris P J G Lafeber, Joel A G van Roon
Published 2015-01-01

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

by Ana P. Lopes, Ana P. Lopes, Cornelis P. J. Bekker, Cornelis P. J. Bekker, Maarten R. Hillen, Maarten R. Hillen, Sofie L. M. Blokland, Sofie L. M. Blokland, Anneline C. Hinrichs, Anneline C. Hinrichs, Aridaman Pandit, Aridaman Pandit, Aike A. Kruize, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Joel A. G. van Roon, Joel A. G. van Roon
Published 2021-08-01

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I...

by Timothy R D J Radstake, Joel A G van Roon, Maarten R Hillen, Sofie L M Blokland, Aridaman Pandit, Katia Urso, Emma Koppe, Ana Pinheiro Lopes, Tom Slocombe, André van Maurik
Published 2020-08-01

Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren's syndrome.

by Ana P Lopes, Maarten R Hillen, Eleni Chouri, Sofie L M Blokland, Cornelis P J Bekker, Aike A Kruize, Marzia Rossato, Joel A G van Roon, Timothy R D J Radstake
Published 2018-01-01

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

by Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake
Published 2018-07-01

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cells in vitro

by Sandra C. Silva-Cardoso, Sandra C. Silva-Cardoso, Weiyang Tao, Weiyang Tao, Chiara Angiolilli, Chiara Angiolilli, Ana P. Lopes, Ana P. Lopes, Cornelis P. J. Bekker, Cornelis P. J. Bekker, Abhinandan Devaprasad, Abhinandan Devaprasad, Barbara Giovannone, Jaap van Laar, Marta Cossu, Marta Cossu, Wioleta Marut, Wioleta Marut, Erik Hack, Rob J. de Boer, Marianne Boes, Marianne Boes, Timothy R. D. J. Radstake, Timothy R. D. J. Radstake, Aridaman Pandit, Aridaman Pandit
Published 2020-09-01

Fatty Acid and Carnitine Metabolism Are Dysregulated in Systemic Sclerosis Patients

by A. Ottria, A. Ottria, A. T. Hoekstra, M. Zimmermann, M. Zimmermann, M. van der Kroef, M. van der Kroef, N. Vazirpanah, N. Vazirpanah, M. Cossu, M. Cossu, E. Chouri, E. Chouri, M. Rossato, M. Rossato, L. Beretta, R. G. Tieland, R. G. Tieland, C. G. K. Wichers, C. G. K. Wichers, E. Stigter, C. Gulersonmez, F. Bonte-Mineur, C. R. Berkers, C. R. Berkers, T. R. D. J. Radstake, T. R. D. J. Radstake, W. Marut, W. Marut
Published 2020-05-01