The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Anila Hussiani, Roger Hesselstrand, Dirk M Wuttge, Yanhui Deng, Robbert Simms, Erik Lubberts, Robert Lafyatis
Published 2009-06-01

Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression.

by Timothy R D J Radstake, Lenny van Bon, Jasper Broen, Mark Wenink, Kim Santegoets, Yanhui Deng, Anila Hussaini, Robert Simms, William W Cruikshank, Robert Lafyatis
Published 2009-06-01