3C-like proteinase, SARS-CoV-2 ADMET Artemisia Artemisia glauca COVID-19 COVID-19 main protease Coronavirus 3C Proteases Coumarins DFT Dicumarol Ligands Molecular Docking Simulation Molecular Dynamics Simulation Protease Inhibitors SARS-CoV-2 chemistry coumarin coumarin derivative dicoumarol drug therapy jusan coumarin ligand molecular docking molecular dynamics molecular similarity new dicoumarin proteinase inhibitor structure fingerprint toxicity