The Z mutation alters the global structural dynamics of α1-antitrypsin.

by Victoria A Hughes, Robert Meklemburg, Stephen P Bottomley, Patrick L Wintrode
Published 2014-01-01

Conformational behavior and aggregation of ataxin-3 in SDS.

by Helen M Saunders, Victoria A Hughes, Roberto Cappai, Stephen P Bottomley
Published 2013-01-01

The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin.

by Anja S Knaupp, Shani Keleher, Li Yang, Weiwen Dai, Stephen P Bottomley, Mary C Pearce
Published 2013-01-01

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

by Andre L. Samson, Bosco Ho, Amanda E. Au, Simone M. Schoenwaelder, Mark J. Smyth, Stephen P. Bottomley, Oded Kleifeld, Robert L. Medcalf
Published 2016-01-01

Conformational change in the chromatin remodelling protein MENT.

by Poh Chee Ong, Sarah J Golding, Mary C Pearce, James A Irving, Sergei A Grigoryev, Debbie Pike, Christopher G Langendorf, Tanya A Bashtannyk-Puhalovich, Stephen P Bottomley, James C Whisstock, Robert N Pike, Sheena McGowan
Published 2009-01-01

Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin

by Andre L. Samson, Anja S. Knaupp, Maithili Sashindranath, Rachael J. Borg, Amanda E.-L. Au, Elisa J. Cops, Helen M. Saunders, Stephen H. Cody, Catriona A. McLean, Cameron J. Nowell, Victoria A. Hughes, Stephen P. Bottomley, Robert L. Medcalf
Published 2012-10-01

The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates.

by Ruth M Kennan, Wilson Wong, Om P Dhungyel, Xiaoyan Han, David Wong, Dane Parker, Carlos J Rosado, Ruby H P Law, Sheena McGowan, Shane B Reeve, Vita Levina, Glenn A Powers, Robert N Pike, Stephen P Bottomley, A Ian Smith, Ian Marsh, Richard J Whittington, James C Whisstock, Corrine J Porter, Julian I Rood
Published 2010-01-01