Editorial: Fibrinolysis in Immunity

by Krasimir Kolev, Robert L. Medcalf
Published 2020-03-01

Fibrinolysis: A Primordial System Linked to the Immune Response

by Robert L. Medcalf, Charithani B. Keragala
Published 2021-03-01

The Fibrinolytic System: Mysteries and Opportunities

by Robert L. Medcalf, Charithani B. Keragala
Published 2021-06-01

Plasmin, Immunity, and Surgical Site Infection

by Stuart Hastings, Paul S. Myles, Robert L. Medcalf
Published 2021-05-01

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical sim...

by Be’eri Niego, Brad R. S. Broughton, Heidi Ho, Christopher G. Sobey, Robert L. Medcalf
Published 2017-11-01

t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

by Dominik F. Draxler, Felix Lee, Heidi Ho, Charithani B. Keragala, Robert L. Medcalf, Be'eri Niego
Published 2019-03-01

Tissue-Type Plasminogen Activator and Tenecteplase-Mediated Increase in Blood Brain Barrier Permeability Involves Cell Intrinsic Complement

by Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf
Published 2020-12-01

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin.

by Be'eri Niego, Natasha Lee, Pia Larsson, T Michael De Silva, Amanda E-Ling Au, Fiona McCutcheon, Robert L Medcalf
Published 2017-01-01

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

by Andre L. Samson, Bosco Ho, Amanda E. Au, Simone M. Schoenwaelder, Mark J. Smyth, Stephen P. Bottomley, Oded Kleifeld, Robert L. Medcalf
Published 2016-01-01

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.

by Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, Sebastian Lunke, Assam El-Osta, Assam El-Osta, Robert L Medcalf, Per-Arne Svensson, Lena Karlsson, Sverker Jern
Published 2012-01-01

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

by Maria Daglas, Dominik F. Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E. Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L. Medcalf
Published 2019-10-01

The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis.

by Lisa Cm Dahl, Zeyad Nasa, JieYu Chung, Be'eri Niego, Volga Tarlac, Heidi Ho, Adam Galle, Steven Petratos, Jae Young Lee, Frank Alderuccio, Robert L Medcalf
Published 2016-01-01

Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin.

by Rachael J Borg, Andre L Samson, Amanda E-L Au, Anja Scholzen, Martina Fuchsberger, Ying Y Kong, Roxann Freeman, Nicole A Mifsud, Magdalena Plebanski, Robert L Medcalf
Published 2015-01-01

Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin

by Andre L. Samson, Anja S. Knaupp, Maithili Sashindranath, Rachael J. Borg, Amanda E.-L. Au, Elisa J. Cops, Helen M. Saunders, Stephen H. Cody, Catriona A. McLean, Cameron J. Nowell, Victoria A. Hughes, Stephen P. Bottomley, Robert L. Medcalf
Published 2012-10-01

Plasmin Generation Potential and Recanalization in Acute Ischaemic Stroke; an Observational Cohort Study of Stroke Biobank Samples

by Thomas Lillicrap, Thomas Lillicrap, Charithani B. Keragala, Dominik F. Draxler, Dominik F. Draxler, Dominik F. Draxler, Jilly Chan, Heidi Ho, Stevi Harman, Be'eri Niego, Elizabeth Holliday, Elizabeth Holliday, Christopher R. Levi, Christopher R. Levi, Christopher R. Levi, Carlos Garcia-Esperon, Carlos Garcia-Esperon, Neil Spratt, Neil Spratt, Prajwal Gyawali, Prajwal Gyawali, Andrew Bivard, Andrew Bivard, Andrew Bivard, Mark W. Parsons, Joan Montaner, Joan Montaner, Joan Montaner, Alejandro Bustamante, Israel Fernandez Cadenas, Geoffrey Cloud, Geoffrey Cloud, Jane M. Maguire, Lisa Lincz, Lisa Lincz, Lisa Lincz, Timothy Kleinig, Timothy Kleinig, John Attia, John Attia, Simon Koblar, Simon Koblar, Monica Anne Hamilton-Bruce, Monica Anne Hamilton-Bruce, Philip Choi, Philip Choi, Bradford B. Worrall, Bradford B. Worrall, Robert L. Medcalf
Published 2020-11-01