Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

by Siri Tähtinen, Saija Kaikkonen, Maiju Merisalo-Soikkeli, Susanna Grönberg-Vähä-Koskela, Anna Kanerva, Suvi Parviainen, Markus Vähä-Koskela, Akseli Hemminki
Published 2015-01-01

A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

by Cristian Capasso, Aniket Magarkar, Victor Cervera-Carrascon, Manlio Fusciello, Sara Feola, Martin Muller, Mariangela Garofalo, Lukasz Kuryk, Siri Tähtinen, Lucio Pastore, Alex Bunker, Vincenzo Cerullo
Published 2017-09-01

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

by Riikka Havunen, João M. Santos, Suvi Sorsa, Tommi Rantapero, Dave Lumen, Mikko Siurala, Anu J. Airaksinen, Victor Cervera-Carrascon, Siri Tähtinen, Anna Kanerva, Akseli Hemminki
Published 2018-12-01

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

by Sadia Zafar, Suvi Parviainen, Mikko Siurala, Otto Hemminki, Riikka Havunen, Siri Tähtinen, Simona Bramante, Lotta Vassilev, Hongjie Wang, Andre Lieber, Silvio Hemmi, Tanja de Gruijl, Anna Kanerva, Akseli Hemminki
Published 2017-02-01

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

by Riikka Havunen, Mikko Siurala, Suvi Sorsa, Susanna Grönberg-Vähä-Koskela, Michael Behr, Siri Tähtinen, João Manuel Santos, Pauliina Karell, Juuso Rusanen, Dirk M. Nettelbeck, Anja Ehrhardt, Anna Kanerva, Akseli Hemminki
Published 2017-03-01

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

by Mathias Vormehr, Sophie Lehar, Lena M. Kranz, Siri Tahtinen, Yoko Oei, Vincent Javinal, Lélia Delamarre, Kerstin C. Walzer, Mustafa Diken, Sebastian Kreiter, Ira Mellman, Ugur Sahin, Jill M. Schartner, Özlem Türeci
Published 2020-01-01

Artificially cloaked viral nanovaccine for cancer immunotherapy

by Manlio Fusciello, Flavia Fontana, Siri Tähtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylösmäki, Erkko Ylösmäki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Hélder A. Santos, Vincenzo Cerullo
Published 2019-12-01

Overcoming tumor resistance by heterologous adeno-poxvirus combination therapy

by Markus Vähä-Koskela, Siri Tähtinen, Susanna Grönberg-Vähä-Koskela, Kristian Taipale, Dipongkor Saha, Maiju Merisalo-Soikkeli, Marko Ahonen, Noora Rouvinen-Lagerström, Mari Hirvinen, Ville Veckman, Sampsa Matikainen, Fang Zhao, Päivi Pakarinen, Jarmo Salo, Anna Kanerva, Vincenzo Cerullo, Akseli Hemminki
Published 2014-01-01