Potent Preclinical Efficacy of DuoHexaBody-CD37 in B-Cell Malignancies

by Hilma J. van der Horst, Simone C. Oostindie, Saskia. A. G. M. Cillessen, Anne T. Gelderloos, Marije B. Overdijk, Inger. S. Nijhof, Sonja Zweegman, Martine E. D. Chamuleau, Esther C. W. Breij, Tuna Mutis
Published 2021-01-01

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.

by Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Published 2016-01-01

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

by Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij
Published 2020-02-01