Neutralization of IL-8 prevents the induction of dermatologic adverse events associated with the inhibition of epidermal growth factor receptor.

by Nannie Bangsgaard, Mischa Houtkamp, Danita H Schuurhuis, Paul W H I Parren, Ole Baadsgaard, Hans W M Niessen, Lone Skov
Published 2012-01-01

Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys.

by Wendelien B Oswald, Thomas W Geisbert, Kelly J Davis, Joan B Geisbert, Nancy J Sullivan, Peter B Jahrling, Paul W H I Parren, Dennis R Burton
Published 2007-01-01

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

by Aran F. Labrijn, Joyce I. Meesters, Matthew Bunce, Anthony A. Armstrong, Sandeep Somani, Tom C. Nesspor, Mark L. Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W. H. I. Parren
Published 2017-05-01

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.

by Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Published 2016-01-01

A directed molecular evolution approach to improved immunogenicity of the HIV-1 envelope glycoprotein.

by Sean X Du, Li Xu, Wenge Zhang, Susan Tang, Rebecca I Boenig, Helen Chen, Ellaine B Mariano, Michael B Zwick, Paul W H I Parren, Dennis R Burton, Terri Wrin, Christos J Petropoulos, John A Ballantyne, Michael Chambers, Robert G Whalen
Published 2011-01-01

Oncogenic KRAS Impairs EGFR Antibodies' Efficiency by C/EBPβ-Dependent Suppression of EGFR Expression

by Stefanie Derer, Sven Berger, Martin Schlaeth, Tanja Schneider-Merck, Katja Klausz, Stefan Lohse, Marije B. Overdijk, Michael Dechant, Christian Kellner, Iris Nagelmeier, Andreas H. Scheel, Jeroen J. Lammerts van Bueren, Jan G.J. van de Winkel, Paul W.H.I. Parren, Matthias Peipp, Thomas Valerius
Published 2012-03-01

DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing

by Patrick J. Engelberts, Ida H. Hiemstra, Bart de Jong, Danita H. Schuurhuis, Joyce Meesters, Irati Beltran Hernandez, Simone C. Oostindie, Joost Neijssen, Edward N. van den Brink, G. Jean Horbach, Sandra Verploegen, Aran F. Labrijn, Theodora Salcedo, Janine Schuurman, Paul W.H.I Parren, Esther C.W. Breij
Published 2020-02-01

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

by Mario Losen, Aran F. Labrijn, Vivianne H. van Kranen-Mastenbroek, Maarten L. Janmaat, Krista G. Haanstra, Frank J. Beurskens, Tom Vink, Margreet Jonker, Bert A. ‘t Hart, Marina Mané-Damas, Peter C. Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H. de Baets, Paul W. H. I. Parren
Published 2017-04-01

Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.

by Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz M Wilczynski, Malgorzata Lekka, Patrick J Engelberts, Wendy J M Mackus, Elzbieta Gorska, Lukasz Bojarski, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Anna Dabrowska-Iwanicka, Grzegorz W Basak, Maria Wasik, Krzysztof Warzocha, Maciej Sinski, Zbigniew Gaciong, Marek Jakobisiak, Paul W H I Parren, Jakub Golab
Published 2008-03-01