Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

by Simon W. M. John, Simon W. M. John, Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Brynn H. Cardozo, Kelly E. Cochran
Published 2017-04-01

Schlemm's canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process.

by Krishnakumar Kizhatil, Margaret Ryan, Jeffrey K Marchant, Stephen Henrich, Simon W M John
Published 2014-07-01

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice

by James R. Tribble, Jeffrey M. Harder, Pete A. Williams, Simon W. M. John
Published 2020-05-01

Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.

by Ryan H Berry, Juan Qu, Simon W M John, Gareth R Howell, Tatjana C Jakobs
Published 2015-01-01

Nicotinamide treatment robustly protects from inherited mouse glaucoma

by Pete A. Williams, Jeffrey M. Harder, Brynn H. Cardozo, Nicole E. Foxworth, Simon W. M. John
Published 2018-01-01

GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma

by Pete A. Williams, Catherine E. Braine, Nicole E. Foxworth, Kelly E. Cochran, Simon W. M. John
Published 2017-04-01

DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

by Ileana Soto, Gareth R Howell, Cai W John, Joseph L Kief, Richard T Libby, Simon W M John
Published 2014-01-01

Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.

by Richard T Libby, Yan Li, Olga V Savinova, Joseph Barter, Richard S Smith, Robert W Nickells, Simon W M John
Published 2005-07-01

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17

by K. Saidas Nair, Mihai Cosma, Narayanan Raghupathy, Michael A. Sellarole, Nicholas G. Tolman, Wilhelmine de Vries, Richard S. Smith, Simon W. M. John
Published 2016-08-01

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

by Pete A Williams, Gareth R Howell, Jessica M Barbay, Catherine E Braine, Gregory L Sousa, Simon W M John, James E Morgan
Published 2013-01-01

Mutations in a P-type ATPase gene cause axonal degeneration.

by Xianjun Zhu, Richard T Libby, Wilhelmine N de Vries, Richard S Smith, Dana L Wright, Roderick T Bronson, Kevin L Seburn, Simon W M John
Published 2012-01-01

Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

by Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John
Published 2014-11-01

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death

by Kimberly A. Fernandes, Jeffrey M. Harder, Laura B. Fornarola, Robert S. Freeman, Abbot F. Clark, Iok-Hou Pang, Simon W.M. John, Richard T. Libby
Published 2012-05-01

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice

by Jeffrey M. Harder, Pete A. Williams, Catherine E. Braine, Hongtian S. Yang, Jocelyn M. Thomas, Nicole E. Foxworth, Simon W. M. John, Gareth R. Howell
Published 2020-11-01

Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.

by Laura G Reinholdt, Gareth R Howell, Anne M Czechanski, Danilo G Macalinao, Katharine H Macnicoll, Chyuan-Sheng Lin, Leah Rae Donahue, Simon W M John
Published 2012-01-01

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

by Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Published 2019-01-01

Mutations in zebrafish lrp2 result in adult-onset ocular pathogenesis that models myopia and other risk factors for glaucoma.

by Kerry N Veth, Jason R Willer, Ross F Collery, Matthew P Gray, Gregory B Willer, Daniel S Wagner, Mary C Mullins, Ava J Udvadia, Richard S Smith, Simon W M John, Ronald G Gregg, Brian A Link
Published 2011-02-01

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

by Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman, Syed Hameed, Yusef Seymens, Eric Dang, Anil K. Mandal, Sirisha Senthil, Rohit C. Khanna, Meha Kabra, Inderjeet Kaur, Simon W. M. John, Subhabrata Chakrabarti, K. Saidas Nair
Published 2020-05-01

Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice

by Nicholas G. Tolman, Revathi Balasubramanian, Danilo G. Macalinao, Alison L. Kearney, Katharine H. MacNicoll, Christa L. Montgomery, Wilhelmine N. de Vries, Ian J. Jackson, Sally H. Cross, Krishnakumar Kizhatil, K. Saidas Nair, Simon W. M. John
Published 2021-02-01

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

by Hélène Choquet, Seyyedhassan Paylakhi, Stephen C. Kneeland, Khanh K. Thai, Thomas J. Hoffmann, Jie Yin, Mark N. Kvale, Yambazi Banda, Nicholas G. Tolman, Pete A. Williams, Catherine Schaefer, Ronald B. Melles, Neil Risch, Simon W. M. John, K. Saidas Nair, Eric Jorgenson
Published 2018-06-01