Amino Acid Sequence Article Catalytic Domain Crystal structure Dihydroorotase Drug target Genomics Malates Models, Molecular Plasmodium falciparum Pyrimidines Sequence Homology, Amino Acid Vibrio cholera Vibrio cholerae Yersinia pestis Zinc amino acid sequence bacterial growth biosynthesis carboxy terminal sequence chemistry comparative study controlled study crystal structure dihydroorotase enzyme active site enzymology genetics genomics ligand binding