Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island.

by Albert G Remacle, Sergey A Shiryaev, Alex Y Strongin
Published 2014-01-01

Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase.

by Sergey A Shiryaev, Anton V Cheltsov, Alex Y Strongin
Published 2012-01-01

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

by Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin and Maurizio Pellecchia
Published 2020-05-01

A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.

by Katarzyna Gawlik, Albert G Remacle, Sergey A Shiryaev, Vladislav S Golubkov, Mingxing Ouyang, Yingxiao Wang, Alex Y Strongin
Published 2010-06-01

Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.

by Sergey A Shiryaev, Alexei Y Savinov, Piotr Cieplak, Boris I Ratnikov, Khatereh Motamedchaboki, Jeffrey W Smith, Alex Y Strongin
Published 2009-01-01

Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.

by Katarzyna Gawlik, Sergey A Shiryaev, Wenhong Zhu, Khatereh Motamedchaboki, Roxane Desjardins, Robert Day, Albert G Remacle, Boguslaw Stec, Alex Y Strongin
Published 2009-01-01

New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

by Sergey A Shiryaev, Elliot R Thomsen, Piotr Cieplak, Eugene Chudin, Anton V Cheltsov, Mark S Chee, Igor A Kozlov, Alex Y Strongin
Published 2012-01-01

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

by Sergey A Shiryaev, Andrei V Chernov, Vladislav S Golubkov, Elliot R Thomsen, Eugene Chudin, Mark S Chee, Igor A Kozlov, Alex Y Strongin, Piotr Cieplak
Published 2013-01-01

Zika Virus: Origins, Pathological Action, and Treatment Strategies

by Kirill Gorshkov, Sergey A. Shiryaev, Sophie Fertel, Yi-Wen Lin, Chun-Teng Huang, Antonella Pinto, Chen Farhy, Alex Y. Strongin, Wei Zheng, Alexey V. Terskikh
Published 2019-01-01

The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.

by Youngsoon Kim, Albert G Remacle, Andrei V Chernov, Huaqing Liu, Igor Shubayev, Calvin Lai, Jennifer Dolkas, Sergey A Shiryaev, Vladislav S Golubkov, Andrew P Mizisin, Alex Y Strongin, Veronica I Shubayev
Published 2012-01-01