A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

by Elizabeth X Kwan, Eric J Foss, Scott Tsuchiyama, Gina M Alvino, Leonid Kruglyak, Matt Kaeberlein, M K Raghuraman, Bonita J Brewer, Brian K Kennedy, Antonio Bedalov
Published 2013-01-01

Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

by Yanhua Yao, Scott Tsuchiyama, Ciyu Yang, Anne Laure Bulteau, Chong He, Brett Robison, Mitsuhiro Tsuchiya, Delana Miller, Valeria Briones, Krisztina Tar, Anahi Potrero, Bertrand Friguet, Brian K Kennedy, Marion Schmidt
Published 2015-01-01

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

by Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Published 2011-09-01