Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response.

by Vyacheslav M Labunskyy, Maxim V Gerashchenko, Joe R Delaney, Alaattin Kaya, Brian K Kennedy, Matt Kaeberlein, Vadim N Gladyshev
Published 2014-01-01

Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

by Shai White‐Gilbertson, Ping Lu, Christian M. Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R. Delaney, James S. Norris, Christina Voelkel‐Johnson
Published 2020-05-01

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.

by Undine Kruegel, Brett Robison, Thomas Dange, Günther Kahlert, Joe R Delaney, Soumya Kotireddy, Mitsuhiro Tsuchiya, Scott Tsuchiyama, Christopher J Murakami, Jennifer Schleit, George Sutphin, Daniel Carr, Krisztina Tar, Gunnar Dittmar, Matt Kaeberlein, Brian K Kennedy, Marion Schmidt
Published 2011-09-01

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors.

by Joe R Delaney, Chandni B Patel, Jaidev Bapat, Christian M Jones, Maria Ramos-Zapatero, Katherine K Ortell, Ralph Tanios, Mina Haghighiabyaneh, Joshua Axelrod, John W DeStefano, Isabelle Tancioni, David D Schlaepfer, Olivier Harismendy, Albert R La Spada, Dwayne G Stupack
Published 2020-01-01

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast

by Matthew M. Crane, Mitsuhiro Tsuchiya, Ben W. Blue, Jared D. Almazan, Kenneth L. Chen, Siobhan R. Duffy, Alexandra Golubeva, Annaiz M. Grimm, Alison M. Guard, Shauna A. Hill, Ellen Huynh, Ryan M. Kelly, Michael Kiflezghi, Hyunsung D. Kim, Mitchell Lee, Ting-I. Lee, Jiayi Li, Bao M.G. Nguyen, Riley M. Whalen, Feng Y. Yeh, Mark McCormick, Brian K. Kennedy, Joe R. Delaney, Matt Kaeberlein
Published 2019-01-01