FGF19 and FGF21: In NASH we trust

by Saswata Talukdar, Alexei Kharitonenkov
Published 2021-04-01

The mechanism mediating the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317

by Saswata Talukdar, F. Bradley Hillgartner
Published 2006-11-01

Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317

by Saswata Talukdar, Sushant Bhatnagar, Sami Dridi, F. Bradley Hillgartner
Published 2007-12-01

Knock-down of IL-1Ra in obese mice decreases liver inflammation and improves insulin sensitivity.

by Niclas Franck, Michael Maris, Sarah Nalbandian, Saswata Talukdar, Simon Schenk, Hans-Peter Hofmann, David Bullough, Olivia Osborn
Published 2014-01-01

Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes.

by Darwin V Lee, Dongmei Li, Qingyun Yan, Yimin Zhu, Bryan Goodwin, Roberto Calle, Martin B Brenner, Saswata Talukdar
Published 2014-01-01

Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models

by Yohei Tomita, Zhongjie Fu, Zhongxiao Wang, Bertan Cakir, Steve S. Cho, William Britton, Ye Sun, Ann Hellström, Saswata Talukdar, Lois E.H. Smith
Published 2020-02-01

Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient ob...

by Yan Weng, Jeffrey R Chabot, Barbara Bernardo, Qingyun Yan, Yimin Zhu, Martin B Brenner, Chandra Vage, Alison Logan, Roberto Calle, Saswata Talukdar
Published 2015-01-01

Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice.

by Justin Chapman, Philip D Miles, Jachelle M Ofrecio, Jaap G Neels, Joseph G Yu, Jamie L Resnik, Jason Wilkes, Saswata Talukdar, Divya Thapar, Kristen Johnson, Dorothy D Sears
Published 2010-11-01

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration

by Zhongjie Fu, Chenxi Qiu, Gael Cagnone, Yohei Tomita, Shuo Huang, Bertan Cakir, Yumi Kotoda, William Allen, Edward Bull, James D. Akula, Jean-Sébastien Joyal, Ann Hellström, Saswata Talukdar, Lois E.H. Smith
Published 2021-04-01

FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice

by Zhongjie Fu, Yan Gong, Raffael Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Steven S. Meng, Samuel B. Burnim, Nicholas J. Saba, Thomas W. Fredrick, Peyton C. Morss, Ann Hellstrom, Saswata Talukdar, Lois E.H. Smith
Published 2017-02-01

FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasi...

by Emilio P. Mottillo, Eric M. Desjardins, Andreas M. Fritzen, Vito Z. Zou, Justin D. Crane, Julian M. Yabut, Bente Kiens, Derek M. Erion, Adhiraj Lanba, James G. Granneman, Saswata Talukdar, Gregory R. Steinberg
Published 2017-06-01

Photoreceptor glucose metabolism determines normal retinal vascular growth

by Zhongjie Fu, Chatarina A Löfqvist, Raffael Liegl, Zhongxiao Wang, Ye Sun, Yan Gong, Chi‐Hsiu Liu, Steven S Meng, Samuel B Burnim, Ivana Arellano, My T Chouinard, Rubi Duran, Alexander Poblete, Steve S Cho, James D Akula, Michael Kinter, David Ley, Ingrid Hansen Pupp, Saswata Talukdar, Ann Hellström, Lois EH Smith
Published 2018-01-01

Discovery of a new class of integrin antibodies for fibrosis

by Ji Zhang, Tao Wang, Ashmita Saigal, Josephine Johnson, Jennifer Morrisson, Sahba Tabrizifard, Scott A. Hollingsworth, Michael J. Eddins, Wenxian Mao, Kim O’Neill, Margarita Garcia-Calvo, Ester Carballo-Jane, DingGang Liu, Taewon Ham, Qiong Zhou, Weifeng Dong, Hsien-Wei Meng, Jacqueline Hicks, Tian-Quan Cai, Taro Akiyama, Shirly Pinto, Alan C. Cheng, Thomas Greshock, John C. Marquis, Zhao Ren, Saswata Talukdar, Hussam Hisham Shaheen, Masahisa Handa
Published 2021-01-01

Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis

by Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiao-Lan Shen, Tian-Quan Cai, Kashmira Shah, Ester Carballo-Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li-Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea M. Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian K. Jensen, Shirly Pinto
Published 2020-07-01