Longitudinal stability of urinary extracellular vesicle protein patterns within and between individuals

by Leyla A. Erozenci, Sander R. Piersma, Thang V. Pham, Irene V. Bijnsdorp, Connie R. Jimenez
Published 2021-08-01

Optimized Combination of HDACI and TKI Efficiently Inhibits Metabolic Activity in Renal Cell Carcinoma and Overcomes Sunitinib Resistance

by Magdalena Rausch, Andrea Weiss, Marloes Zoetemelk, Sander R. Piersma, Connie R. Jimenez, Judy R. van Beijnum, Patrycja Nowak-Sliwinska
Published 2020-10-01

Exosomal ITGA3 interferes with non-cancerous prostate cell functions and is increased in urine exosomes of metastatic prostate cancer patients

by Irene V. Bijnsdorp, Albert A. Geldof, Mehrdad Lavaei, Sander R. Piersma, R. Jeroen A. van Moorselaar, Connie R. Jimenez
Published 2013-10-01

Mycosins Are Required for the Stabilization of the ESX-1 and ESX-5 Type VII Secretion Membrane Complexes

by Vincent J. C. van Winden, Roy Ummels, Sander R. Piersma, Connie R. Jiménez, Konstantin V. Korotkov, Wilbert Bitter, Edith N. G. Houben
Published 2016-10-01

Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes

by Frederik J. Verweij, Cecilia de Heus, Stefanie Kroeze, Houjian Cai, Elliott Kieff, Sander R. Piersma, Connie R. Jimenez, Jaap M. Middeldorp, Dirk Michiel Pegtel
Published 2015-04-01

Feasibility of urinary extracellular vesicle proteome profiling using a robust and simple, clinically applicable isolation method

by Irene V. Bijnsdorp, Olga Maxouri, Aarzo Kardar, Tim Schelfhorst, Sander R. Piersma, Thang V. Pham, Andre Vis, R. Jeroen van Moorselaar, Connie R. Jimenez
Published 2017-12-01

Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells

by Dennis Poel, Lenka N.C. Boyd, Robin Beekhof, Tim Schelfhorst, Thang V. Pham, Sander R. Piersma, Jaco C. Knol, Connie R. Jimenez, Henk M.W. Verheul, Tineke E. Buffart
Published 2019-09-01

Peptide-mediated ‘miniprep’ isolation of extracellular vesicles is suitable for high-throughput proteomics

by Jaco C. Knol, Inge de Reus, Tim Schelfhorst, Robin Beekhof, Meike de Wit, Sander R. Piersma, Thang V. Pham, Egbert F. Smit, Henk M.W. Verheul, Connie R. Jiménez
Published 2016-06-01

Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

by Franziska Böttger, Ekaterina A. Semenova, Ji-Ying Song, Giustina Ferone, Jan van der Vliet, Miranda Cozijnsen, Rajith Bhaskaran, Lorenzo Bombardelli, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Anton Berns
Published 2019-06-01

Effects of Cancer Presence and Therapy on the Platelet Proteome

by Maudy Walraven, Siamack Sabrkhany, Jaco C. Knol, Henk Dekker, Inge de Reus, Sander R. Piersma, Thang V. Pham, Arjan W. Griffioen, Henk J. Broxterman, Mirjam Oude Egbrink, Henk M. W. Verheul, Connie R. Jimenez
Published 2021-07-01

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF.

by Trang H Phan, Lisanne M van Leeuwen, Coen Kuijl, Roy Ummels, Gunny van Stempvoort, Alba Rubio-Canalejas, Sander R Piersma, Connie R Jiménez, Astrid M van der Sar, Edith N G Houben, Wilbert Bitter
Published 2018-08-01

Sex-Related Differences in Protein Expression in Sarcomere Mutation-Positive Hypertrophic Cardiomyopathy

by Maike Schuldt, Larissa M. Dorsch, Jaco C. Knol, Thang V. Pham, Tim Schelfhorst, Sander R. Piersma, Cris dos Remedios, Cris dos Remedios, Michelle Michels, Connie R. Jimenez, Diederik W. D. Kuster, Jolanda van der Velden
Published 2021-03-01

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

by Timo W. M. De Groof, Nick D. Bergkamp, Raimond Heukers, Truc Giap, Maarten P. Bebelman, Richard Goeij-de Haas, Sander R. Piersma, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Marco Siderius, Martine J. Smit
Published 2021-07-01

Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

by Tessa Ya Sung Le Large, Btissame El Hassouni, Niccola Funel, Bart Kok, Sander R. Piersma, Thang V. Pham, Kenneth P. Olive, Geert Kazemier, Hanneke W.M. van Laarhoven, Connie R. Jimenez, Maarten F. Bijlsma, Elisa Giovannetti
Published 2019-05-01

Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer

by Johannes C. van der Mijn, Nik Sol, Wouter Mellema, Connie R. Jimenez, Sander R. Piersma, Henk Dekker, Lisette M. Schutte, Egbert F. Smit, Henk J. Broxterman, Johan Skog, Bakhos A. Tannous, Thomas Wurdinger, Henk M. W. Verheul
Published 2014-12-01

Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins.

by Musa Sani, Edith N G Houben, Jeroen Geurtsen, Jason Pierson, Karin de Punder, Maaike van Zon, Brigitte Wever, Sander R Piersma, Connie R Jiménez, Mamadou Daffé, Ben J Appelmelk, Wilbert Bitter, Nicole van der Wel, Peter J Peters
Published 2010-03-01

Quantitative Phosphoproteomic Analysis Reveals Dendritic Cell- Specific STAT Signaling After α2-3–Linked Sialic Acid Ligand Binding

by Rui-Jún Eveline Li, Aram de Haas, Ernesto Rodríguez, Hakan Kalay, Anouk Zaal, Connie R. Jimenez, Sander R. Piersma, Thang V. Pham, Alex A. Henneman, Richard R. de Goeij-de Haas, Sandra J. van Vliet, Yvette van Kooyk
Published 2021-04-01

Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment

by Judy R. van Beijnum, Andrea Weiss, Robert H. Berndsen, Tse J. Wong, Louise C. Reckman, Sander R. Piersma, Marloes Zoetemelk, Richard de Haas, Olivier Dormond, Axel Bex, Alexander A. Henneman, Connie R. Jimenez, Arjan W. Griffioen, Patrycja Nowak-Sliwinska
Published 2020-09-01

PKCα-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis.

by Viola Kooij, Pingbo Zhang, Sander R Piersma, Vasco Sequeira, Nicky M Boontje, Paul J M Wijnker, Connie R Jiménez, Kornelia E Jaquet, Cris dos Remedios, Anne M Murphy, Jennifer E Van Eyk, Jolanda van der Velden, Ger Jm Stienen
Published 2013-01-01

Phosphoproteomic Characterization of Primary AML Samples and Relevance for Response Toward FLT3-inhibitors

by David G. J. Cucchi, Carolien Van Alphen, Sonja Zweegman, Bo Van Kuijk, Zinia J. Kwidama, Adil al Hinai, Alexander A. Henneman, Jaco C. Knol, Sander R. Piersma, Thang V. Pham, Connie R. Jimenez, Jacqueline Cloos, Jeroen J. W. M. Janssen
Published 2021-07-01