Stem Cell Research: Promise and Progress

by Rudolf Jaenisch, MD
Published 2015-06-01

Response to “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”

by Hui Yang, Haoyi Wang, Rudolf Jaenisch
Published 2021-04-01

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

by Haiting Ma, Jacob F. Jeppesen, Rudolf Jaenisch
Published 2020-09-01

Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation

by Malkiel A. Cohen, Styliani Markoulaki, Rudolf Jaenisch
Published 2018-05-01

A brief review of genome editing technology for generating animal models

by Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH
Published 2020-06-01

Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.

by Günter Raddatz, Qing Gao, Sebastian Bender, Rudolf Jaenisch, Frank Lyko
Published 2012-01-01

Parent-of-Origin DNA Methylation Dynamics during Mouse Development

by Yonatan Stelzer, Hao Wu, Yuelin Song, Chikdu S. Shivalila, Styliani Markoulaki, Rudolf Jaenisch
Published 2016-09-01

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

by Stefan Semrau, Johanna E. Goldmann, Magali Soumillon, Tarjei S. Mikkelsen, Rudolf Jaenisch, Alexander van Oudenaarden
Published 2017-10-01

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.

by Tamara Major, Jayanthi Menon, Gordon Auyeung, Frank Soldner, Dirk Hockemeyer, Rudolf Jaenisch, Viviane Tabar
Published 2011-01-01

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

by Stamatis Papathanasiou, Styliani Markoulaki, Logan J. Blaine, Mitchell L. Leibowitz, Cheng-Zhong Zhang, Rudolf Jaenisch, David Pellman
Published 2021-10-01

Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex

by Schahram Akbarian, Richard Z Chen, Joost Gribnau, Theodore P Rasmussen, Hiu-fai Fong, Rudolf Jaenisch, Edward G Jones
Published 2001-10-01

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

by Dorothea Maetzel, Sovan Sarkar, Haoyi Wang, Lina Abi-Mosleh, Ping Xu, Albert W. Cheng, Qing Gao, Maisam Mitalipova, Rudolf Jaenisch
Published 2014-06-01

Neurotrophin-3 Promotes Cell Death Induced in Cerebral Ischemia, Oxygen-Glucose Deprivation, and Oxidative Stress: Possible Involvement of Oxygen Free Radicals

by Brian Bates, Lorenz Hirt, Sunu S. Thomas, Schahram Akbarian, Dean Le, Sepideh Amin-Hanjani, Michael Whalen, Rudolf Jaenisch, Michael A. Moskowitz
Published 2002-02-01

Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype

by Attya Omer Javed, Yun Li, Julien Muffat, Kuan-Chung Su, Malkiel A. Cohen, Tenzin Lungjangwa, Patrick Aubourg, Iain M. Cheeseman, Rudolf Jaenisch
Published 2018-10-01

SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

by Michael A Lodato, Christopher W Ng, Joseph A Wamstad, Albert W Cheng, Kevin K Thai, Ernest Fraenkel, Rudolf Jaenisch, Laurie A Boyer
Published 2013-01-01

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.

by Kimberly D Siegmund, Caroline M Connor, Mihaela Campan, Tiffany I Long, Daniel J Weisenberger, Detlev Biniszkiewicz, Rudolf Jaenisch, Peter W Laird, Schahram Akbarian
Published 2007-01-01

A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells.

by Grace X Y Zheng, Arvind Ravi, J Mauro Calabrese, Lea A Medeiros, Oktay Kirak, Lucas M Dennis, Rudolf Jaenisch, Christopher B Burge, Phillip A Sharp
Published 2011-05-01

Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells

by John P. Cassady, Ana C. D’Alessio, Sovan Sarkar, Vardhan S. Dani, Zi Peng Fan, Kibibi Ganz, Reinhard Roessler, Mriganka Sur, Richard A. Young, Rudolf Jaenisch
Published 2014-12-01

An Endogenously Tagged Fluorescent Fusion Protein Library in Mouse Embryonic Stem Cells

by Arigela Harikumar, Raghu Ram Edupuganti, Matan Sorek, Gajendra Kumar Azad, Styliani Markoulaki, Petra Sehnalová, Soňa Legartová, Eva Bártová, Shlomit Farkash-Amar, Rudolf Jaenisch, Uri Alon, Eran Meshorer
Published 2017-10-01

Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

by Shafqat A. Khan, Kyoung-mi Park, Laura A. Fischer, Chen Dong, Tenzin Lungjangwa, Marta Jimenez, Dominick Casalena, Brian Chew, Sabine Dietmann, Douglas S. Auld, Rudolf Jaenisch, Thorold W. Theunissen
Published 2021-06-01