A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.

by Yu-Kang Cheng, Rameen Beroukhim, Ross L Levine, Ingo K Mellinghoff, Eric C Holland, Franziska Michor
Published 2012-01-01

Mesenchymal Cell Reprogramming in Experimental MPLW515L Mouse Model of Myelofibrosis.

by Ying Han, Lanzhu Yue, Max Wei, Xiubao Ren, Zonghong Shao, Ling Zhang, Ross L Levine, Pearlie K Epling-Burnette
Published 2017-01-01

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

by Ioana I. Nitulescu, Sara C. Meyer, Qiang Jeremy Wen, John D. Crispino, Madeleine E. Lemieux, Ross L. Levine, Henry E. Pelish, Matthew D. Shair
Published 2017-12-01

Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

by Serena De Vita, Rebekka K Schneider, Michael Garcia, Jenna Wood, Mathilde Gavillet, Benjamin L Ebert, Alexander Gerbaulet, Axel Roers, Ross L Levine, Ann Mullally, David A Williams
Published 2014-01-01

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone

by Jonas S. Jutzi, Maria Kleppe, Jennifer Dias, Hans Felix Staehle, Kaitlyn Shank, Julie Teruya-Feldstein, Sudheer Madan Mohan Gambheer, Christine Dierks, Hugh Y. Rienhoff, Jr, Ross L. Levine, Heike L. Pahl
Published 2018-06-01

The Polycomb Group Protein L3MBTL1 Represses a SMAD5-Mediated Hematopoietic Transcriptional Program in Human Pluripotent Stem Cells

by Fabiana Perna, Ly P. Vu, Maria Themeli, Sonja Kriks, Ruben Hoya-Arias, Raya Khanin, Todd Hricik, Jorge Mansilla-Soto, Eirini P. Papapetrou, Ross L. Levine, Lorenz Studer, Michel Sadelain, Stephen D. Nimer
Published 2015-04-01

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

by Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Published 2016-12-01

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms

by Manon Viaud, Omar Abdel-Wahab, Julie Gall, Stoyan Ivanov, Rodolphe Guinamard, Sophie Sore, Johanna Merlin, Marion Ayrault, Emma Guilbaud, Arnaud Jacquel, Patrick Auberger, Nan Wang, Ross L. Levine, Alan R. Tall, Laurent Yvan-Charvet
Published 2020-03-01

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

by Jing Fang, Tomoya Muto, Maria Kleppe, Lyndsey C. Bolanos, Kathleen M. Hueneman, Callum S. Walker, Leesa Sampson, Ashley M. Wellendorf, Kashish Chetal, Kwangmin Choi, Nathan Salomonis, Yongwon Choi, Yi Zheng, Jose A. Cancelas, Ross L. Levine, Daniel T. Starczynowski
Published 2018-01-01

DOT1L inhibitors block abnormal self-renewal induced by cohesin loss

by Katelyn E. Heimbruch, Joseph B. Fisher, Cary T. Stelloh, Emily Phillips, Michael H. Reimer, Adam J. Wargolet, Alison E. Meyer, Kirthi Pulakanti, Aaron D. Viny, Jessica J. Loppnow, Ross L. Levine, John Anto Pulikkan, Nan Zhu, Sridhar Rao
Published 2021-03-01

Detection of Marker-Free Precision Genome Editing and Genetic Variation through the Capture of Genomic Signatures

by Pierre Billon, Tarun S. Nambiar, Samuel B. Hayward, Maria P. Zafra, Emma M. Schatoff, Koichi Oshima, Andrew Dunbar, Marco Breinig, Young C. Park, Han S. Ryu, Darjus F. Tschaharganeh, Ross L. Levine, Richard Baer, Adolfo Ferrando, Lukas E. Dow, Alberto Ciccia
Published 2020-03-01

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.

by Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Benjamin L Ebert, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D Gary Gilliland, Ross L Levine
Published 2006-07-01

Central Role of ULK1 in Type I Interferon Signaling

by Diana Saleiro, Swarna Mehrotra, Barbara Kroczynska, Elspeth M. Beauchamp, Pawel Lisowski, Beata Majchrzak-Kita, Tushar D. Bhagat, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Ewa M. Kosciuczuk, Darren P. Baker, Chunfa Jie, Nadereh Jafari, Craig B. Thompson, Ross L. Levine, Eleanor N. Fish, Amit K. Verma, Leonidas C. Platanias
Published 2015-04-01

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species

by Hongliang Zong, Alexander Gozman, Eloisi Caldas-Lopes, Tony Taldone, Eric Sturgill, Sarah Brennan, Stefan O. Ochiana, Erica M. Gomes-DaGama, Siddhartha Sen, Anna Rodina, John Koren III, Michael W. Becker, Charles M. Rudin, Ari Melnick, Ross L. Levine, Gail J. Roboz, Stephen D. Nimer, Gabriela Chiosis, Monica L. Guzman
Published 2015-12-01

A precision medicine classification for treatment of acute myeloid leukemia in older patients

by Alice S. Mims, Jessica Kohlschmidt, Uma Borate, James S. Blachly, Shelley Orwick, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Deedra Nicolet, Krzysztof Mrόzek, Eytan Stein, Bhavana Bhatnagar, Richard M. Stone, Jonathan E. Kolitz, Eunice S. Wang, Bayard L. Powell, Amy Burd, Ross L. Levine, Brian J. Druker, Clara D. Bloomfield, John C. Byrd
Published 2021-06-01

Clonal hematopoiesis before, during, and after human spaceflight

by Nuria Mencia-Trinchant, Matthew J. MacKay, Christopher Chin, Ebrahim Afshinnekoo, Jonathan Foox, Cem Meydan, Daniel Butler, Christopher Mozsary, Nicholas A. Vernice, Charlotte Darby, Michael C. Schatz, Susan M. Bailey, Ari M. Melnick, Monica L. Guzman, Kelly Bolton, Lior Z. Braunstein, Francine Garrett-Bakelman, Ross L. Levine, Duane C. Hassane, Christopher E. Mason
Published 2021-02-01

Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis

by Jozef Madzo, Hui Liu, Alexis Rodriguez, Aparna Vasanthakumar, Sriram Sundaravel, Donne Bennett D. Caces, Timothy J. Looney, Li Zhang, Janet B. Lepore, Trisha Macrae, Robert Duszynski, Alan H. Shih, Chun-Xiao Song, Miao Yu, Yiting Yu, Robert Grossman, Brigitte Raumann, Amit Verma, Chuan He, Ross L. Levine, Don Lavelle, Bruce T. Lahn, Amittha Wickrema, Lucy A. Godley
Published 2014-01-01

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing

by Li Zhang, Ngoc-Tung Tran, Hairui Su, Rui Wang, Yuheng Lu, Haiping Tang, Sayura Aoyagi, Ailan Guo, Alireza Khodadadi-Jamayran, Dewang Zhou, Kun Qian, Todd Hricik, Jocelyn Côté, Xiaosi Han, Wenping Zhou, Suparna Laha, Omar Abdel-Wahab, Ross L Levine, Glen Raffel, Yanyan Liu, Dongquan Chen, Haitao Li, Tim Townes, Hengbin Wang, Haiteng Deng, Y George Zheng, Christina Leslie, Minkui Luo, Xinyang Zhao
Published 2015-11-01

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

by Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kathy Q. Cai, Lisa Beatrice Caruso, Julian Swatler, Michal Dabrowski, Zhaorui Lian, Peter Valent, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Jian Huang, Grant A. Challen, Daniel Link, Italo Tempera, Mariusz A. Wasik, Katarzyna Piwocka, Tomasz Skorski
Published 2020-10-01

Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis

by Teng Gao, Ryan Ptashkin, Kelly L. Bolton, Maria Sirenko, Christopher Fong, Barbara Spitzer, Kamal Menghrajani, Juan E. Arango Ossa, Yangyu Zhou, Elsa Bernard, Max Levine, Juan S. Medina Martinez, Yanming Zhang, Sebastià Franch-Expósito, Minal Patel, Lior Z. Braunstein, Daniel Kelly, Mariko Yabe, Ryma Benayed, Nicole M. Caltabellotta, John Philip, Ederlinda Paraiso, Simon Mantha, David B. Solit, Luis A. Diaz, Michael F. Berger, Virginia Klimek, Ross L. Levine, Ahmet Zehir, Sean M. Devlin, Elli Papaemmanuil
Published 2021-01-01