Development of Relaxin-3 Agonists and Antagonists Based on Grafted Disulfide-Stabilized Scaffolds

by Han Siean Lee, Michael Postan, Angela Song, Richard J. Clark, Ross A. D. Bathgate, Ross A. D. Bathgate, Linda M. Haugaard-Kedström, K. Johan Rosengren
Published 2020-02-01

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

by Alexander D. Wykes, Sherie Ma, Ross A.D. Bathgate, Andrew L. Gundlach
Published 2020-06-01

C-terminus of the B-chain of relaxin-3 is important for receptor activity.

by Fazel Shabanpoor, Ross A D Bathgate, John D Wade, Mohammed Akhter Hossain
Published 2013-01-01

In a Class of their own – RXFP1 and RXFP2 are unique members of the LGR family

by Emma June Petrie, Emma June Petrie, Samantha eLagaida, Samantha eLagaida, Ashish eSethi, Ashish eSethi, Ross A.D. Bathgate, Ross A.D. Bathgate, Paul Raymond Gooley, Paul Raymond Gooley
Published 2015-09-01

Characterisation of a cell-free synthesised G-protein coupled receptor

by Patrick J. Shilling, Fabian Bumbak, Daniel J. Scott, Ross A. D. Bathgate, Paul R. Gooley
Published 2017-04-01

Synthetic Covalently Linked Dimeric Form of H2 Relaxin Retains Native RXFP1 Activity and Has Improved In Vitro Serum Stability

by Vinojini B. Nair, Ross A. D. Bathgate, Frances Separovic, Chrishan S. Samuel, Mohammed Akhter Hossain, John D. Wade
Published 2015-01-01

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

by Bryna Suet Man Chow, Elaine Guo Yan Chew, Chongxin Zhao, Ross A D Bathgate, Tim D Hewitson, Chrishan S Samuel
Published 2012-01-01

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists

by Han Siean Lee, Shu Hui Wang, James T. Daniel, Mohammed Akhter Hossain, Richard J. Clark, Ross A. D. Bathgate, K. Johan Rosengren
Published 2020-10-01

Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function.

by Gabrielle E Callander, Sherie Ma, Despina E Ganella, Verena C Wimmer, Andrew L Gundlach, Walter G Thomas, Ross A D Bathgate
Published 2012-01-01

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

by Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley
Published 2016-04-01

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

by Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate
Published 2019-01-01

Diazepam is not a direct allosteric modulator of α1‐adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase‐4

by Lisa M. Williams, Xiaoji He, Tasneem M. Vaid, Alaa Abdul‐Ridha, Alice R. Whitehead, Paul R. Gooley, Ross A.D. Bathgate, Spencer J. Williams, Daniel J. Scott
Published 2019-02-01

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

by Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J. Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J. Petrie, Paul R. Gooley, Ross A. D. Bathgate
Published 2017-06-01

Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

by Phillip L. van der Peet, Christian Gunawan, Alaa Abdul-Ridha, Sherie Ma, Daniel J. Scott, Andrew L. Gundlach, Ross A.D. Bathgate, Jonathan M. White, Spencer J. Williams
Published 2018-01-01

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

by Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, Jingbo Xiao, Juan J. Marugan, Mohammed A. Hossain, Chao Wang, Dana S. Hutchinson, Chrishan S. Samuel, Alexander I. Agoulnik, Ross A. D. Bathgate, Roger J. Summers
Published 2017-06-01

Relaxin-2 Does Not Ameliorate Nephropathy in an Experimental Model of Type-1 Diabetes

by Thomas Bernd Dschietzig, Katharina Krause-Relle, Maud Hennequin, Karoline von Websky, Jan Rahnenführer, Jana Ruppert, Hans Jürgen Grön, Franz Paul Armbruster, Ross A. D. Bathgate, Joerg R. Aschenbach, Wolf-Georg Forssmann, Berthold Hocher
Published 2015-03-01

Activation of Relaxin Family Receptor 1 from different mammalian species by relaxin peptide and small molecule agonist ML290

by Zaohua eHuang, Courtney eMyhr, Ross A.D. Bathgate, Brian eHo, Amaya eBueno, Xin eHu, Jingbo eXiao, Noel eSouthall, Elena eBarnaeva, Irina U Agoulnik, Juan eMarugan, Marc eFerrer, Alexander I Agoulnik
Published 2015-08-01