Behind the Wheel of Epithelial Plasticity in KRAS-Driven Cancers

by Emily N. Arner, Wenting Du, Rolf A. Brekken, Rolf A. Brekken
Published 2019-10-01

TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy

by Adam S. Dayoub, Rolf A. Brekken
Published 2020-02-01

Phosphorylation of Akt and ERK1/2 is required for VEGF-A/VEGFR2-induced proliferation and migration of lymphatic endothelium.

by Michael T Dellinger, Rolf A Brekken
Published 2011-01-01

Perspectives on Hypoxia Signaling in Tumor Stroma

by Yuqing Zhang, Morgan Coleman, Rolf A. Brekken
Published 2021-06-01

VEGF and Pleiotrophin Modulate the Immune Profile of Breast Cancer

by Kristi D. Lynn, Christina L. Roland, Rolf A. Brekken
Published 2010-05-01

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature.

by Michael T Dellinger, Stryder M Meadows, Katherine Wynne, Ondine Cleaver, Rolf A Brekken
Published 2013-01-01

Molecular and Clinical Aspects of Targeting the VEGF Pathway in Tumors

by Grzegorz Korpanty, Laura A. Sullivan, Elizabeth Smyth, Desmond N. Carney, Rolf A. Brekken
Published 2010-01-01

Loss of Tbk1 kinase activity protects mice from diet-induced metabolic dysfunction

by Victoria H. Cruz, Emily N. Arner, Katherine W. Wynne, Philipp E. Scherer, Rolf A. Brekken
Published 2018-10-01

Cytokine levels correlate with immune cell infiltration after anti-VEGF therapy in preclinical mouse models of breast cancer.

by Christina L Roland, Kristi D Lynn, Jason E Toombs, Sean P Dineen, D Gomika Udugamasooriya, Rolf A Brekken
Published 2009-11-01

P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer

by Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L. Greiner, Rolf A. Brekken, Craig W. Vander Kooi, Arthur M. Mercurio
Published 2016-03-01

Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

by Shanna A Arnold, Lee B Rivera, Juliet G Carbon, Jason E Toombs, Chi-Lun Chang, Amy D Bradshaw, Rolf A Brekken
Published 2012-01-01

r84, a novel therapeutic antibody against mouse and human VEGF with potent anti-tumor activity and limited toxicity induction.

by Laura A Sullivan, Juliet G Carbon, Christina L Roland, Jason E Toombs, Mari Nyquist-Andersen, Anita Kavlie, Kyle Schlunegger, James A Richardson, Rolf A Brekken
Published 2010-08-01

Lack of “immunological fitness” during fasting in metabolically challenged animals

by Ingrid Wernstedt Asterholm, John McDonald, Pierre-Gilles Blanchard, Madhur Sinha, Qiang Xiao, Jehangir Mistry, Joseph M. Rutkowski, Yves Deshaies, Rolf A. Brekken, Philipp E. Scherer
Published 2012-07-01

Targeting interleukin-6 as a strategy to overcome stroma-induced resistance to chemotherapy in gastric cancer

by In-Hye Ham, Hye Jeong Oh, Hyejin Jin, Cheong A Bae, Sang-Min Jeon, Kyeong Sook Choi, Sang-Yong Son, Sang-Uk Han, Rolf A. Brekken, Dakeun Lee, Hoon Hur
Published 2019-03-01

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

by Qian Wu, Tomonori Ishikawa, Rosa Sirianni, Hao Tang, Jeffrey G. McDonald, Ivan S. Yuhanna, Bonne Thompson, Luc Girard, Chieko Mineo, Rolf A. Brekken, Michihisa Umetani, David M. Euhus, Yang Xie, Philip W. Shaul
Published 2013-11-01

Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis.

by Chieko Mineo, Lane Lanier, Eunjeong Jung, Samarpita Sengupta, Victoria Ulrich, Anastasia Sacharidou, Cristina Tarango, Olutoye Osunbunmi, Yu-Min Shen, Jane E Salmon, Rolf A Brekken, Xianming Huang, Philip E Thorpe, Philip W Shaul
Published 2016-01-01

SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

by Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar, Michael G. Roth
Published 2017-01-01

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer

by Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Published 2019-11-01

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

by Ozhan Ocal, Victor Pashkov, Rahul K. Kollipara, Yalda Zolghadri, Victoria H. Cruz, Michael A. Hale, Blake R. Heath, Alex B. Artyukhin, Alana L. Christie, Pantelis Tsoulfas, James B. Lorens, Galvin H. Swift, Rolf A. Brekken, Thomas M. Wilkie
Published 2015-10-01

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan

by Chensu Wang, Hanspeter Niederstrasser, Peter M. Douglas, Rueyling Lin, Juan Jaramillo, Yang Li, Nathaniel W. Oswald, Anwu Zhou, Elizabeth A. McMillan, Saurabh Mendiratta, Zhaohui Wang, Tian Zhao, Zhiqaing Lin, Min Luo, Gang Huang, Rolf A. Brekken, Bruce A. Posner, John B. MacMillan, Jinming Gao, Michael A. White
Published 2017-12-01