Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation

by Farzana Chowdhury, Farzana Chowdhury, Anwar Tappuni, Michele Bombardieri
Published 2021-07-01

Accumulation of self-reactive naïve and memory B cell reveals sequential defects in B cell tolerance checkpoints in Sjögren's syndrome.

by Elisa Corsiero, Nurhan Sutcliffe, Costantino Pitzalis, Michele Bombardieri
Published 2014-01-01

Ectopic Lymphoid Structures: powerhouse of autoimmunity

by Elisa Corsiero, Alessandra Nerviani, Michele Bombardieri, Costantino Pitzalis
Published 2016-10-01

NETosis as source of autoantigens in rheumatoid arthritis

by Elisa Corsiero, Federico Pratesi, Edoardo Prediletto, Michele Bombardieri, Paola Migliorini
Published 2016-11-01

Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium.

by Frances Humby, Michele Bombardieri, Antonio Manzo, Stephen Kelly, Mark C Blades, Bruce Kirkham, Jo Spencer, Costantino Pitzalis
Published 2009-01-01

Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus

by Michele Bombardieri, Daniele Mauro, Felice Rivellese, Debasish Pyne, Myles J Lewis, Sotiria Manou-Stathopoulou, Ravindra Rajakariar, Peter Schafer
Published 2021-09-01

Kidney Expression of Toll Like Receptors in Lupus Nephritis: Quantification and Clinicopathological Correlations

by Fabrizio Conti, Francesca Romana Spinelli, Simona Truglia, Francesca Miranda, Cristiano Alessandri, Fulvia Ceccarelli, Michele Bombardieri, Konstantinos Giannakakis, Guido Valesini
Published 2016-01-01

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.

by Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D'Acquisto, Elliot J Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M Marelli-Berg, Claudio Mauro
Published 2015-07-01

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.

by Giorgia Fanelli, Marco Romano, Estefania Nova-Lamperti, Mariana Werner Sunderland, Alessandra Nerviani, Cristiano Scottà, Michele Bombardieri, Sergio A Quezada, Steven H Sacks, Randolph J Noelle, Costantino Pitzalis, Robert I Lechler, Giovanna Lombardi, Pablo D Becker
Published 2021-04-01

A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNFα-Blockade in Rheumatoid Arthritis Patients

by Alessandra Nerviani, Maria Di Cicco, Arti Mahto, Gloria Lliso-Ribera, Felice Rivellese, Georgina Thorborn, Rebecca Hands, Mattia Bellan, Daniele Mauro, Marie-Astrid Boutet, Giovanni Giorli, Myles Lewis, Stephen Kelly, Michele Bombardieri, Frances Humby, Costantino Pitzalis
Published 2020-05-01

Hepatitis Delta Virus Detected in Salivary Glands of Sjögren’s Syndrome Patients and Recapitulates a Sjögren’s Syndrome-Like Phenotype in Vivo

by Melodie L. Weller, Matthew R. Gardener, Zoe C. Bogus, Michael A. Smith, Elisa Astorri, Drew G. Michael, Donald A. Michael, Changyu Zheng, Peter D. Burbelo, Zhennan Lai, Paul A. Wilson, William Swaim, Beverly Handelman, Sandra A. Afione, Michele Bombardieri, John A. Chiorini
Published 2016-05-01

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus

by Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo
Published 2018-05-01

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

by Yanxia Guo, Alice M Walsh, Mary Canavan, Mihir D Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew Loza, Carl Orr, Trudy McGarry, Michele Bombardieri, Frances Humby, Susanna M Proudman, Costantino Pitzalis, Malcolm D Smith, Joshua R Friedman, Ian Anderson, Loui Madakamutil, Douglas J Veale, Ursula Fearon, Sunil Nagpal
Published 2018-01-01

NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment

by Elena Pontarini, Elisabetta Sciacca, Sofia Grigoriadou, Felice Rivellese, Davide Lucchesi, Liliane Fossati-Jimack, Rachel Coleby, Farzana Chowdhury, Farzana Chowdhury, Francesca Calcaterra, Francesca Calcaterra, Anwar Tappuni, Myles J. Lewis, Martina Fabris, Luca Quartuccio, Silvia Della Bella, Silvia Della Bella, Simon Bowman, Costantino Pitzalis, Domenico Mavilio, Domenico Mavilio, Salvatore De Vita, Michele Bombardieri
Published 2021-09-01

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

by Myles J. Lewis, Michael R. Barnes, Kevin Blighe, Katriona Goldmann, Sharmila Rana, Jason A. Hackney, Nandhini Ramamoorthi, Christopher R. John, David S. Watson, Sarah K. Kummerfeld, Rebecca Hands, Sudeh Riahi, Vidalba Rocher-Ros, Felice Rivellese, Frances Humby, Stephen Kelly, Michele Bombardieri, Nora Ng, Maria DiCicco, Désirée van der Heijde, Robert Landewé, Annette van der Helm-van Mil, Alberto Cauli, Iain B. McInnes, Christopher D. Buckley, Ernest Choy, Peter C. Taylor, Michael J. Townsend, Costantino Pitzalis
Published 2019-08-01

A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome.

by Katherine James, Shereen Al-Ali, Jessica Tarn, Simon J Cockell, Colin S Gillespie, Victoria Hindmarsh, James Locke, Sheryl Mitchell, Dennis Lendrem, Simon Bowman, Elizabeth Price, Colin T Pease, Paul Emery, Peter Lanyon, John A Hunter, Monica Gupta, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Nagui Gendi, Mohammed Akil, Bridget Griffiths, UK Primary Sjögren’s Syndrome registry, Anil Wipat, Julia Newton, David E Jones, John Isaacs, Jennifer Hallinan, Wan-Fai Ng
Published 2015-01-01