Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention

by Matheus Henrique Dias, René Bernards
Published 2021-08-01

Fighting Drug Resistance through the Targeting of Drug-Tolerant Persister Cells

by Giulia De Conti, Matheus Henrique Dias, René Bernards
Published 2021-03-01

The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.

by Jeroen H Nijwening, Ernst-Jan Geutjes, Rene Bernards, Roderick L Beijersbergen
Published 2011-01-01

A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway.

by Jasper Mullenders, Armida W M Fabius, Mandy Madiredjo, René Bernards, Roderick L Beijersbergen
Published 2009-01-01

RUNX2/CBFB modulates the response to MEK inhibitors through activation of receptor tyrosine kinases in KRAS-mutant colorectal cancer

by Tonći Šuštić, Evert Bosdriesz, Sake van Wageningen, Lodewyk F.A. Wessels, René Bernards
Published 2020-02-01

A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.

by Pieter J A Eichhorn, Menno P Creyghton, Kevin Wilhelmsen, Hans van Dam, René Bernards
Published 2007-12-01

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

by Annuska M Glas, Paul Roepman, Laura J van’t Veer, Rene Bernards, Femke de Snoo, Sun Tian
Published 2010-11-01

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

by Sun Tian, Paul Roepman, Laura J van't Veer, Rene Bernards, Femke De Snoo, Annuska M Glas
Published 2010-01-01

Identification of a Druggable Pathway Controlling Glioblastoma Invasiveness

by Nora Pencheva, Mark C. de Gooijer, Daniel J. Vis, Lodewyk F.A. Wessels, Tom Würdinger, Olaf van Tellingen, René Bernards
Published 2017-07-01

The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.

by Julien Moretti, Patricia Chastagner, Stefano Gastaldello, Sara F Heuss, Annette M Dirac, René Bernards, Maria G Masucci, Alain Israël, Christel Brou
Published 2010-11-01

RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells

by Simona Lamba, Mariangela Russo, Chong Sun, Luca Lazzari, Carlotta Cancelliere, Wipawadee Grernrum, Cor Lieftink, Rene Bernards, Federica Di Nicolantonio, Alberto Bardelli
Published 2014-09-01

Correction to: A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Published 2021-02-01

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

by Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Published 2018-11-01

Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.

by James A Walker, Jean Y Gouzi, Jennifer B Long, Sidong Huang, Robert C Maher, Hongjing Xia, Kheyal Khalil, Arjun Ray, David Van Vactor, René Bernards, André Bernards
Published 2013-11-01

Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data

by Subarna Sinha, Daniel Thomas, Steven Chan, Yang Gao, Diede Brunen, Damoun Torabi, Andreas Reinisch, David Hernandez, Andy Chan, Erinn B. Rankin, Rene Bernards, Ravindra Majeti, David L. Dill
Published 2017-05-01

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

by Liqin Wang, Rodrigo Leite de Oliveira, Cun Wang, João M. Fernandes Neto, Sara Mainardi, Bastiaan Evers, Cor Lieftink, Ben Morris, Fleur Jochems, Lisa Willemsen, Roderick L. Beijersbergen, René Bernards
Published 2017-10-01

A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Lik...

by Sjors G. J. G. In ’t Veld, Kim N. Duong, Mireille Snel, Anke Witteveen, Inès J. Beumer, Leonie J.M.J. Delahaye, Diederik Wehkamp, René Bernards, Annuska M. Glas, Sun Tian
Published 2017-11-01

A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

by Haojie Jin, Siying Wang, Esther A Zaal, Cun Wang, Haiqiu Wu, Astrid Bosma, Fleur Jochems, Nikita Isima, Guangzhi Jin, Cor Lieftink, Roderick Beijersbergen, Celia R Berkers, Wenxin Qin, Rene Bernards
Published 2020-10-01

Prognostic Value of MammaPrint in Invasive Lobular Breast Cancer

by Inès J. Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J. van 't Veer, Rene Bernards, Annuska M. Glas
Published 2016-01-01

Prognostic Value of MammaPrint® in Invasive Lobular Breast Cancer

by Inès J. Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J. van 't Veer, Rene Bernards, Annuska M. Glas
Published 2016-12-01