The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

by Marco Gatti, Ralph Imhof, Qingyao Huang, Michael Baudis, Matthias Altmeyer
Published 2020-08-01

Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin

by Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer
Published 2017-05-01

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

by Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof, Matthias Altmeyer
Published 2018-07-01

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

by Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer
Published 2021-06-01

Impact of ribonucleotide incorporation by DNA polymerases β and λ on oxidative base excision repair

by Emmanuele Crespan, Antonia Furrer, Marcel Rösinger, Federica Bertoletti, Elisa Mentegari, Giulia Chiapparini, Ralph Imhof, Nathalie Ziegler, Shana J. Sturla, Ulrich Hübscher, Barbara van Loon, Giovanni Maga
Published 2016-02-01

Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins

by Kathrin Nowak, Florian Rosenthal, Tobias Karlberg, Mareike Bütepage, Ann-Gerd Thorsell, Birgit Dreier, Jonas Grossmann, Jens Sobek, Ralph Imhof, Bernhard Lüscher, Herwig Schüler, Andreas Plückthun, Deena M. Leslie Pedrioli, Michael O. Hottiger
Published 2020-10-01

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks

by Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum
Published 2020-11-01